A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting

The flow of cerebrospinal fluid (CSF) is important for conveying brain-derived macromolecules for signaling and enabling them to be drained from the brain parenchyma. The glymphatic route is the best-characterized means of this CSF flow; however, it does not permit the movement of larger macromolecu...

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Published in:	Nature neuroscience 2025-07, Vol.28 (7), p.1436-1445
Main Authors:	Plog, Benjamin A., Kim, Kyungdeok, Verhaege, Daan, Kim, Min Woo, Papadopoulos, Zachary, Dikranian, Krikor, Dykstra, Taitea, Cao, Jay, Perrin, Richard J., Schwetye, Katherine E., Kipnis, Jonathan, Drieu, Antoine
Format:	Article
Language:	English
Subjects:	13/51 14/34 14/35 14/63 14/69 631/250/371 631/378/1341 631/378/371 64/60 Amyloidosis Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Blood vessels Brain Brain - metabolism Cerebrospinal fluid Cerebrospinal Fluid - metabolism Cerebrospinal Fluid - physiology Collagen Fibroblasts Fluid flow Fluorescence Fluorescent indicators Glymphatic System - physiology Immune clearance Immune system Immunosurveillance Lectins Macromolecular Substances - cerebrospinal fluid Macromolecular Substances - metabolism Macromolecules Male Meningeal Arteries - physiology Meninges Meninges - blood supply Mice Mice, Inbred C57BL Mice, Transgenic Neurobiology Neurosciences Parenchyma Peptides Variance analysis Veins & arteries
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