An INS‐1 832/13 ‐Cell Proteome Highlights the Rapid Regulation of Fatty Acid Biosynthesis in Glucose‐Stimulated Insulin Secretion

Pancreatic beta cells secrete insulin in response to rising glucose levels, a process known as glucose-stimulated insulin secretion (GSIS). Here, we acquire proteomes of rat pancreatic INS-1 832/13 beta cells that were short-term stimulated with 11 different glucose concentrations from 0 to 20 mM, q...

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Bibliographic Details
Published in:	Proteomics (Weinheim) 2025-08, Vol.25 (15), p.13-26
Main Authors:	Stremmel, Nina, Lemke, Oliver, Textoris‐Taube, Kathrin, Ludwig, Daniela, Mülleder, Michael, Muenzner, Julia, Ralser, Markus
Format:	Article
Language:	English
Subjects:	Abundance Animals Beta cells Biosynthesis Catabolism Cell Line Chemoreception Clustering Diabetes mellitus Electron transport Exocytosis Fatty acids Fatty Acids - biosynthesis Glucose Glucose - metabolism Glucose - pharmacology Glycolysis Insulin Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Lipids Metabolic pathways Metabolism Pancreas Protein transport Proteins Proteome - analysis Proteome - metabolism Proteomes Proteomics Proteomics - methods Rats SNAP receptors Stimulation Tricarboxylic acid cycle
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