Dravet syndrome: novel insights into SCN1A-mediated epileptic neurodevelopmental disorders within the molecular diagnostic-therapeutic framework

Dravet Syndrome (DS), a rare genetic encephalopathy characterized by severe drug-resistant epilepsy and progressive neurodevelopmental regression in infancy, is caused by de novo mutations in the SCN1A gene on chromosome 2q24 in over 80% of cases. This review synthesizes current insights into its mo...

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Bibliographic Details
Published in:Frontiers in neuroscience 2025-07, Vol.19, p.1634718
Main Authors: Zhang, Guirui, Huang, Shupeng, Wei, Mingzhen, Wu, Yongmo, Xie, Zhengyi, Wang, Jin
Format: Article
Language:English
Subjects:
antisence oligonucleotides
Dravet syndrom
GABAergic
molecular
Neuroscience
SCN1A
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