Artificial Gametogenesis and In Vitro Spermatogenesis: Emerging Strategies for the Treatment of Male Infertility

Male-factor infertility accounts for approxiamately half of all infertility cases globally, yet therapeutic options remain limited for individuals with no retrievable spermatozoa, such as those with non-obstructive azoospermia (NOA). In recent years, artificial gametogenesis has emerged as a promisi...

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Bibliographic Details
Published in:International journal of molecular sciences 2025-07, Vol.26 (15), p.7383
Main Authors: Kaltsas, Aris, Kyrgiafini, Maria-Anna, Markou, Eleftheria, Koumenis, Andreas, Mamuris, Zissis, Dimitriadis, Fotios, Zachariou, Athanasios, Chrisofos, Michael, Sofikitis, Nikolaos
Format: Article
Language:English
Subjects:
Androgens
Animals
Bioengineering
Biology
Cell division
DNA methylation
Epigenetics
Fertility
Gametogenesis
Humans
In vitro fertilization
Infertility
Infertility, Male - therapy
Male
Metabolism
Review
Sperm
Spermatogenesis
Stem cells
Testis
Testosterone
Tissue Engineering - methods
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