LC–MS‐Based Serum Pharmacochemistry Combined With Network Pharmacology and Pharmacodynamics to Evaluate the Role of Macromolecular Components in TCMs' Decoction: A Case Study on Qi‐Huo‐Yi‐Fei Decoction for COPD Therapy

Introduction The role of macromolecular components in traditional Chinese medicines (TCMs) decoction remains poorly understood, primarily because of their structural complexity and limited systemic bioavailability. In the modernization of TCMs' decoctions, macromolecular components are often re...

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Bibliographic Details
Published in:Phytochemical analysis 2025-10, Vol.36 (7), p.2148-2181
Main Authors: Yang, Peng, Lv, Hu‐Dong, Wu, Jie, Long, Fang, Zhou, Jing, Wu, Cheng‐Ying, Xu, Jin‐Di, Zhou, Shan‐Shan, Xiao, Qing‐Ling, Li, Song‐Lin, Shen, Hong
Format: Article
Language:English
Subjects:
absorption
animal models
Animals
Apoptosis
Bioavailability
blood serum
Case studies
Chronic obstructive pulmonary disease
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - pharmacokinetics
Drugs, Chinese Herbal - pharmacology
Drugs, Chinese Herbal - therapeutic use
Effectiveness
Ethanol
Herbal medicine
Histopathology
Humans
immunity
Impurities
Inflammation
interleukin-17
Liquid Chromatography-Mass Spectrometry - methods
Lung diseases
Lung Diseases, Obstructive - drug therapy
lung function
macromolecular components
Macromolecular Substances - blood
Macromolecular Substances - chemistry
Macromolecular Substances - pharmacology
Macromolecules
Medicine, Chinese Traditional
Modernization
network pharmacology
Network Pharmacology - methods
Pharmacodynamics
Pharmacology
phytochemicals
protein-protein interactions
Proteins
Pulmonary functions
Qi‐Huo‐Yi‐Fei decoction
Rats
Rats, Sprague-Dawley
Respiratory function
respiratory tract diseases
serum pharmacochemistry
therapeutics
Traditional Chinese medicine
UPLC‐QTOF‐MS/MS
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