Identification of susceptibility loci using a novel murine model for triple-negative breast cancer

Abstract Triple-negative breast cancer (TNBC) is the deadliest subtype of breast cancer (BC) with few targeted therapies. To identify novel genetic modifiers of TNBC, we created a murine model incorporating high levels of genetic and phenotypic diversity. C3(1)-T-antigen (“C3Tag”) mice, which develo...

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Bibliographic Details
Published in:G3 : genes - genomes - genetics 2026-02, Vol.16 (2)
Main Authors: Kim, Minjeong, McGrath, Logan G, Mustafa, Zeid T, Eugin Simon, Samson, Pervaiz, Naveed, Grey, Emily W, Joseph, Sydney C, Korba, Emily, Marathe, Sandesh J, Bohm, Margaret S, Ramesh, Arvind V, Mahajan, Sidharth S, Bohl, Casey J, Prins, Pjotr, Read, Robert W, Holt, Jeremiah R, Hayes, D Neil, Lu, Lu, Williams, Robert W, Sipe, Laura M, Ashbrook, David G, Makowski, Liza
Format: Article
Language:English
Subjects:
Animals
Antigens
Breast cancer
Chromosome Mapping
Disease Models, Animal
Female
Genetic Loci
Genetic Predisposition to Disease
Genetics
Humans
Investigation
Mice
Quantitative Trait Loci
Triple Negative Breast Neoplasms - genetics
Triple Negative Breast Neoplasms - mortality
Triple Negative Breast Neoplasms - pathology
Tumors
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