Clobazam versus corticosteroid for developmental and epileptic encephalopathy with spike–wave activation in sleep ((D)EE‐SWAS): Results of a multicenter observational study

Objective Developmental and epileptic encephalopathy with spike–wave activation in sleep ((D)EE‐SWAS) is associated with acquired cognitive and behavioral deficits. This international multicenter study aimed to compare cognitive and safety outcomes following initial treatment with corticosteroid and...

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Published in:	Epilepsia (Copenhagen) 2026-02, Vol.67 (2), p.634-645
Main Authors:	Arnhem, Marleen M. L., Vijn, Linde J., Rubboli, Guido, Khinchi, Marianne Søndergaard, Dimova, Petia, Perucca, Emilio, De Giorgis, Valentina, Metsähonkala, Liisa, Ramantani, Georgia, Jansen, Anna, Chin, Richard, Lagae, Lieven, Arzimanoglou, Alexis, Otte, Wim M., Leijten, Frans S. S., Teeseling, Heleen C., Braun, Kees P. J., Jansen, Floor E., Munckhof, Bart
Format:	Article
Language:	English
Subjects:	(D)EE‐SWAS Adrenal Cortex Hormones - therapeutic use Anticonvulsants - therapeutic use Child Child, Preschool clobazam Clobazam - therapeutic use cognition corticosteroid Diagnosis Electroencephalography Encephalopathy Epilepsy ESES Female Humans Intravenous administration Male Methylprednisolone Methylprednisolone - therapeutic use Prednisolone Retrospective Studies Sleep Sleep - drug effects Sleep - physiology Steroid hormones Steroids Treatment Outcome
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