Diastereo- and Enantioselective Nickel-Catalyzed Intramolecular Reductive Cyclization of Unactivated Alkenes and Aldehydes

Catalytic reductive coupling of unsaturated hydrocarbons with carbonyl compounds provides a streamlined alternative to stoichiometric organometallic additions, yet asymmetric variants that directly engage unactivated alkenes remain limited. Here we report a diastereo- and enantioselective nickel-cat...

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Bibliographic Details
Published in:Organic letters 2026-02, Vol.28 (7), p.2512-2517
Main Authors: Sun, Xiao-Ya, Liu, Xiang-Rui, Huang, Ye-Wei, Zhou, Qi-Lin, Xiao, Li-Jun
Format: Article
Language:English
Subjects:
alkenes
cyclization reactions
diastereomers
enantioselectivity
ligands
reducing agents
stoichiometry
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