Replication competent La Crosse virus pseudotyped VSV vector system as vaccine and serological diagnostic reagent

•LACV Gc/Gn pseudotyped VSV strains were neutralized by LACV-infected patient sera.•Recombinant VSV-LACV strains were not toxic for immunocompetent animals.•Vaccination with LACV-pseudotyped VSV induced strong anti-LACV immune response.•Chimeric VSV-LACV strains were validated as valuable reagents i...

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Bibliographic Details
Published in:Virus research 2026-01, Vol.363, p.199676, Article 199676
Main Authors: Iankov, Ianko, Ammayappan, Arun, Viker, Kimberly, Weisend, Carla, Beard, Matthew, Russell, Brandy, Theel, Elitza, Ebihara, Hideki, Galanis, Evanthia
Format: Article
Language:English
Subjects:
Animals
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
antibody formation
blood serum
California encephalitis orthobunyavirus
cerebrospinal fluid
climate
Culicidae
diagnostic techniques
Dried blood spots
Encephalitis, California - diagnosis
Encephalitis, California - immunology
Encephalitis, California - prevention & control
Encephalitis, California - virology
Female
Genetic Vectors
genetically modified organisms
glycoproteins
Humans
humoral immunity
immunization
interferons
La crosse encephalitis virus
La Crosse virus - genetics
La Crosse virus - immunology
La Crosse virus - physiology
live vaccines
meningoencephalitis
Mice
Mice, Inbred BALB C
monitoring
neutralization
Neutralization Tests
Pseudotyped vsv
Serologic Tests - methods
Serology
seroprevalence
species
Vaccine
Vaccines, Attenuated - administration & dosage
Vaccines, Attenuated - genetics
Vaccines, Attenuated - immunology
Vesicular stomatitis Indiana virus - genetics
Vesiculovirus
Vesiculovirus - genetics
viral encephalitis
Viral Vaccines - administration & dosage
Viral Vaccines - genetics
Viral Vaccines - immunology
Virus neutralization
Virus Replication
viruses
Citations: Items that this one cites
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