Synthesis and structural conformation of N-substituted 1,4-dihyropyridine derivatives

N‐(Phenyl)‐3,5‐dicarbethoxy‐2,6‐dimethyl‐4‐(phenyl)‐1,4‐dihydropyridine (A) and N‐(4‐methoxy phenyl)‐‐3,5 dicarbethoxy‐2,6 dimethyl‐4‐(3‐nitro phenyl)‐1,4‐dihydropyridine (B) has been synthesized as per scheme and characterized by the X‐ray diffraction method. The compound A crystallizes in monoclin...

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Published in:Crystal research and technology (1979) 2006-01, Vol.41 (1), p.92-97
Main Authors: Mahendra, M., Doreswamy, B. H., Sridhar, M. A., Shashidhara Prasad, J., Parecha, A. R., Patel, J. A., Manvar, D., Dholaria, K., Shah, A.
Format: Article
Language:English
Subjects:
4-dihyropyridine
crystal structure
N-substituted 1
N‐substituted 1,4‐dihyropyridine
synthesis
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Summary:N‐(Phenyl)‐3,5‐dicarbethoxy‐2,6‐dimethyl‐4‐(phenyl)‐1,4‐dihydropyridine (A) and N‐(4‐methoxy phenyl)‐‐3,5 dicarbethoxy‐2,6 dimethyl‐4‐(3‐nitro phenyl)‐1,4‐dihydropyridine (B) has been synthesized as per scheme and characterized by the X‐ray diffraction method. The compound A crystallizes in monoclinic space group P21/c with cell parameters a = 9.2770(11)Å, b = 8.6410(5)Å, c = 27.601(3)Å, β = 97.724(3)°, Z = 4. The compound B crystallizes in monoclinic space group P21/c with cell parameters a = 11.229(6), b = 12.746(7)Å, c =17.606(6)Å, β = 104.531(3)°, Z = 4. The structures exhibit both intra and intermolecular hydrogen bonds. Dihydropyridine ring of both the compounds adopt a flat boat conformation. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
ISSN:0232-1300
1521-4079
DOI:10.1002/crat.200310539