Origin of nuclear and chromosomal alterations derived from the action of an aneugenic agent—Trifluralin herbicide

Trifluralin is a herbicide capable of interfering in mitotic cell division due to either microtubule depolymerization or alteration in the concentration of calcium ions within the cell. The aim of this study was to investigate the effects of trifluralin in Allium cepa meristematic cells, evaluating...

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Bibliographic Details
Published in:Ecotoxicology and environmental safety 2009-09, Vol.72 (6), p.1680-1686
Main Authors: Fernandes, Thaís Cristina Casimiro, Mazzeo, Dânia Elisa Christofoletti, Marin-Morales, Maria Aparecida
Format: Article
Language:English
Subjects:
Allium cepa
Alterations
Aneugenic
Aneugens - toxicity
Cell division
Chromosome Aberrations
DNA Damage
Herbicides
Herbicides - toxicity
Mitosis
Mitosis - drug effects
Mutagenicity Tests
Nuclear engineering
Nuclear safety
Onions - drug effects
Onions - genetics
Onions - metabolism
Origins
Phases
Plant Roots - drug effects
Plant Roots - metabolism
Supernumerary microtubule-organizing center
Trifluralin - toxicity
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Summary:Trifluralin is a herbicide capable of interfering in mitotic cell division due to either microtubule depolymerization or alteration in the concentration of calcium ions within the cell. The aim of this study was to investigate the effects of trifluralin in Allium cepa meristematic cells, evaluating the induction mechanisms of the chromosomal and nuclear aberrations. In this study, A. cepa root tips were submitted for 24 h treatment to several concentrations of this herbicide and 48 h recovery post-treatment. The results showed that some concentrations of trifluralin can lead to a mitotic index inhibition, besides inducing chromosomal and nuclear alterations throughout the mitotic cycle. Some of the alterations found seem to be resulting from the herbicide action in different phases and in more than one consecutive cell cycle.
ISSN:0147-6513
1090-2414
DOI:10.1016/j.ecoenv.2009.03.014