Drug Seeking Becomes Compulsive after Prolonged Cocaine Self-Administration

Compulsive drug use in the face of adverse consequences is a hallmark feature of addiction, yet there is little preclinical evidence demonstrating the actual progression from casual to compulsive drug use. Presentation of an aversive conditioned stimulus suppressed drug seeking in rats with limited...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2004-08, Vol.305 (5686), p.1017-1019
Main Authors: Louk J. M. J. Vanderschuren, Everitt, Barry J.
Format: Article
Language:English
Subjects:
Addictive behaviors
Adult and adolescent clinical studies
Animal behavior
Animals
Appetitive Behavior
Behavior, Addictive
Behavioral neuroscience
Biological and medical sciences
Cocaine
Cocaine - administration & dosage
Cocaine abuse
Cocaine-Related Disorders
Compulsive behavior
Compulsive behaviour
Conditioning, Psychological
Control Groups
Cues
Drug addiction
Drug use
Electroshock
Fear
Feedback (Response)
Fetal cocaine exposure
Freezing
Laboratory rats
Male
Medical sciences
Mental stimulation
Models, Animal
Neuropsychology
Physiological aspects
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychopharmacology
Rats
Rats as laboratory animals
Reaction Time
Recreational drugs
Reinforcement, Psychology
Reward
Rodents
Self Administration
Self Control
Statistical Analysis
Stimuli
Substance Abuse
Sucrose - administration & dosage
Time Factors
Veterinary drugs
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Summary:Compulsive drug use in the face of adverse consequences is a hallmark feature of addiction, yet there is little preclinical evidence demonstrating the actual progression from casual to compulsive drug use. Presentation of an aversive conditioned stimulus suppressed drug seeking in rats with limited cocaine self-administration experience, but no longer did so after an extended cocaine-taking history. In contrast, after equivalent extended sucrose experience, sucrose seeking was still suppressed by an aversive conditioned stimulus. Persistent cocaine seeking in the presence of signals of environmental adversity after a prolonged cocaine-taking history was not due to impaired fear conditioning, nor to an increase in the incentive value of cocaine, and may reflect the establishment of compulsive behavior.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1098975