The Effect of Elevated Temperature on Carbon Monoxide-Induced Incapacitation

Laboratory rats were exposed to experimental concentrations of carbon monoxide in air at ambient temperature, to elevated temperature at mospheres from 40°C to 60°C, and to selected CO concentrations in 40-60°C whole-body environments. Incapacitating potency was evaluated by measuring time-to-incapa...

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Bibliographic Details
Published in:Journal of fire sciences 1991-07, Vol.9 (4), p.296-310
Main Authors: Sanders, Donald C., Endecott, Boyd R.
Format: Article
Language:English
Subjects:
Fires
Toxicology
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Summary:Laboratory rats were exposed to experimental concentrations of carbon monoxide in air at ambient temperature, to elevated temperature at mospheres from 40°C to 60°C, and to selected CO concentrations in 40-60°C whole-body environments. Incapacitating potency was evaluated by measuring time-to-incapacitation as a function of CO concentration and/or temperature. Incapacitation occurred earlier when CO inhalation was combined with elevated temperature than when the same parameters were applied individ ually ; a fractionally additive effect was noted. An empirical equation was derived for predicting time-to-incapacitation from CO concentration and tem perature data.
ISSN:0734-9041
1530-8049
DOI:10.1177/073490419100900405