saturated fatty acid-rich diet induces an obesity-linked proinflammatory gene expression profile in adipose tissue of subjects at risk of metabolic syndrome

BACKGROUND: Changes in dietary fat composition could lower the risk of developing metabolic syndrome. Adipose tissue is an interesting tissue in this respect because of its role in lipid metabolism and inflammation. OBJECTIVE: Our objective was to investigate the effect of a saturated fatty acid (SF...

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Bibliographic Details
Published in:	The American journal of clinical nutrition 2009-12, Vol.90 (6), p.1656-1664
Main Authors:	van Dijk, Susan J, Feskens, Edith JM, Bos, Marieke B, Hoelen, Dianne WM, Heijligenberg, Rik, Bromhaar, Mechteld Grootte, de Groot, Lisette CPGM, de Vries, Jeanne HM, Müller, Michael, Afman, Lydia A
Format:	Article
Language:	English
Subjects:	accumulation activated receptor-alpha Adiponectin Adiponectin - blood Adiponectin - genetics Adipose tissue Adipose Tissue - metabolism administration & dosage Adult Aged analysis Biological and medical sciences blood blood lipids blood mononuclear-cells Body fat Chemokine CCL5 Chemokine CCL5 - blood Cholesterol Complement C3 Complement C3 - analysis Diet diet therapy diet-related diseases disease prevention Fatty Acids Fatty Acids - administration & dosage Feeding. Feeding behavior Female food intake functional foods Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling Genes genetics glucose-metabolism health status healthy-men high fat diet human health Humans Immunohistochemistry inflammation inflammation-related genes Insulin Insulin Resistance lipid metabolism Lipids Lipids - blood Male Metabolic disorders Metabolic syndrome Metabolic Syndrome - metabolism metabolism Middle Aged middle-aged adults nonobese pima-indians nutritional status Obesity Oligonucleotide Array Sequence Analysis phenotype plasma PPAR gamma PPAR gamma - genetics protective effect risk factors saturated fatty acids special diets Tissues Vertebrates: anatomy and physiology, studies on body, several organs or systems weight-loss
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