Polyozellin Isolated from Polyozellus multiplex Induces Phase 2 Enzymes in Mouse Hepatoma Cells and Differentiation in Human Myeloid Leukaemic Cell Lines

Induction of cellular phase 2 detoxifying enzymes is associated with cancer preventive potential. Quinone reductase (QR) has been used as a prototype for anticarcinogenic phase 2 enzymes because of its widespread distribution in mammalian systems, large amplitude of inducer response, and ease of mea...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2004-02, Vol.52 (3), p.451-455
Main Authors: Kim, Jeong Hyun, Lee, Jeong Soon, Song, Kyung-Sik, Kwon, Chong-Suk, Kim, Young Kyoon, Kim, Jong-Sang
Format: Article
Language:English
Subjects:
Agaricales - chemistry
Animals
anticarcinogenic activity
Anticarcinogenic Agents
Biological and medical sciences
cell differentiation
Cell Differentiation - drug effects
cell lines
Dose-Response Relationship, Drug
enzyme activity
Enzyme Induction - drug effects
Furans - isolation & purification
Furans - pharmacology
General pharmacology
glutathione
Glutathione - analysis
glutathione transferase
Glutathione Transferase - biosynthesis
hepatoma
heterocyclic oxygen compounds
Humans
Leukemia, Myeloid - pathology
Liver Neoplasms, Experimental - enzymology
Medical sciences
Methanol
Mice
myeloid leukemia
oxidoreductases
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Polyporales
Tumor Cells, Cultured
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