Nefazodone in out-patient treatment of inhaled cocaine dependence: a randomized double-blind placebo-controlled trial

ABSTRACT Aims  To assess the efficacy of oral nefazodone in the treatment of cocaine dependence. Design  A 10‐week randomized double‐blind clinical trial was performed. Methods  All 210 subjects fulfilled Diagnostic and Statistical Manual version IV (DSM‐IV) criteria for cocaine dependence and were...

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Published in:Addiction (Abingdon, England) England), 2005-04, Vol.100 (4), p.489-494
Main Authors: Passos, Sonia Regina Lambert, Camacho, Luiz Antonio Bastos, Lopes, Claudia S., Borges dos Santos, Maria Angélica
Format: Article
Language:English
Subjects:
Addiction
Addictive behaviors
Administration, Inhalation
Administration, Oral
Adolescent
Adult
Adult and adolescent clinical studies
Aged
Ambulatory Care
Antidepressive Agents, Second-Generation - therapeutic use
Biological and medical sciences
Brazil
Clinical trials
Cocaine
Cocaine dependence treatment
Cocaine-Related Disorders - rehabilitation
Double-Blind Method
double-blind placebo-controlled study
Drug addiction
Drug dependency
Drug therapy
Drugs
Evaluation
Fundamental and applied biological sciences. Psychology
Health
Humans
Medical sciences
Medical sociology
Medical treatment
Middle Aged
Nefazodone
Psychoanalysis
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
randomized controlled trial
Randomized controlled trials
Substance abuse treatment
Treatment
Triazoles - therapeutic use
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Summary:ABSTRACT Aims  To assess the efficacy of oral nefazodone in the treatment of cocaine dependence. Design  A 10‐week randomized double‐blind clinical trial was performed. Methods  All 210 subjects fulfilled Diagnostic and Statistical Manual version IV (DSM‐IV) criteria for cocaine dependence and were assigned randomly to 300 mg/day of oral nefazodone (N) or placebo (P). Self‐reported drug use, retention interval in treatment, adherence to prescription and depressive symptoms were assessed by the Hamilton scale. Findings  Abstinence from cocaine for 3 weeks or more was achieved by 49.5% (N) and 45.7% (P) (P = 0.58), but 16.2% (N) and 22.9% (P) used other drugs during abstinence. The average interval to resumption of drug use was 33.9 days (N) and 36.1 days (P). Adverse effects were reported by 45.8% (N) and 29.5% (P) (P = 0.01). Treatment for these events was needed more often in N (24.0%) than in P (9.5%) (P 
ISSN:0965-2140
1360-0443
DOI:10.1111/j.1360-0443.2005.01041.x