A genetic analysis of smoking behavior in family members of older adult males

Aims. To conduct a genetic study of smoking behavior in 493 three‐generation families. Design. Complex segregation analysis and maximum likelihood statistics were used to describe the familial clustering of ever‐smoking under several transmission models. Setting. The Western Collaborative Group Stud...

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Bibliographic Details
Published in:Addiction (Abingdon, England) England), 2000-03, Vol.95 (3), p.427-435
Main Authors: Cheng, Li Shu-Chuan, Swan, Gary E., Carmelli, Dorit
Format: Article
Language:English
Subjects:
Addiction
Addictive behaviors
Adult and adolescent clinical studies
Aged
Analysis
Biological and medical sciences
Chromosome Segregation
Elderly men
Families
Families & family life
Family
Family Health
Genes, Dominant - genetics
Genetic factors
Genetic Predisposition to Disease - genetics
Genetics
Humans
Interviews
Male
Males
Medical sciences
Models, Genetic
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Sex Factors
Smoking
Social behaviour
Statistics
Tobacco smoking
Tobacco Use Disorder - genetics
United States
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Summary:Aims. To conduct a genetic study of smoking behavior in 493 three‐generation families. Design. Complex segregation analysis and maximum likelihood statistics were used to describe the familial clustering of ever‐smoking under several transmission models. Setting. The Western Collaborative Group Study, an ageing and health study currently in its 39th year of follow‐up. Participants. Probands were male participants who were of mean age 71.6 years at the time of the family history interview in 1986‐88. Measurements. Data were collected via an interview that focused on the family smoking history of participants. Smoking histories of all first‐degree relatives were obtained from probands. Findings. Evidence for genetic transmission was indicated by rejection of both the environmental and sporadic models in favor of a Mendelian genetic model with residual familial effects from spouses and both parents. Conclusions. The best‐fitting model was that of a dominant major gene with low estimated frequency and residual familial correlations. This is the first study to date to model the familial transmission of ever‐smoking in three‐generation families.
ISSN:0965-2140
1360-0443
DOI:10.1046/j.1360-0443.2000.95342713.x