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Double-blind randomized trial of buprenorphine and methadone in opiate dependence
This study compared the safety and efficacy of sublingual buprenorphine tablets with oral methadone in a population of opioid-dependent individuals in a double-blind, randomized, 6-week trial using a flexible dosing procedure. Fifty-eight patients seeking treatment for opioid dependence were recruit...
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| Published in: | Drug and alcohol dependence 2001-03, Vol.62 (1), p.97-104 |
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| Main Authors: | , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c445t-35f74d863bd8953b29e3939411ae1476005023d6ad4cc04341b3fe8406fe99063 |
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| cites | cdi_FETCH-LOGICAL-c445t-35f74d863bd8953b29e3939411ae1476005023d6ad4cc04341b3fe8406fe99063 |
| container_end_page | 104 |
| container_issue | 1 |
| container_start_page | 97 |
| container_title | Drug and alcohol dependence |
| container_volume | 62 |
| creator | Petitjean, Sylvie Stohler, Rudolf Déglon, Jean-Jacques Livoti, Santino Waldvogel, Doris Uehlinger, Claude Ladewig, Dieter |
| description | This study compared the safety and efficacy of sublingual buprenorphine tablets with oral methadone in a population of opioid-dependent individuals in a double-blind, randomized, 6-week trial using a flexible dosing procedure. Fifty-eight patients seeking treatment for opioid dependence were recruited in three outpatient facilities and randomly assigned to substitution with buprenorphine or methadone. The retention rate was significantly better in the methadone maintained group (90 vs. 56%;
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| doi_str_mv | 10.1016/S0376-8716(00)00163-0 |
| format | article |
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P<0.001). Subjects completing the study in both the treatment groups had similar proportions of opioid positive urine samples (buprenorphine 62%; methadone 59%) and positive urine specimens, as well as mean heroin craving scores decreased significantly over time (
P=0.035 and
P<0.001). The proportion of cocaine-positive toxicology results did not differ between groups. At week six mean stabilization doses were 10.5 mg per day for the sublingual buprenorphine tablet, and 69.8 mg per day for methadone, respectively. Patient performance during maintenance was similar in both the groups. The high attrition rate in the buprenorphine group during the induction phase might reflect inadequate induction doses. Thus, buprenorphine is a viable alternative for methadone in short-term maintenance treatment for heroin dependence if treatment induction is done with adequate dosages.</description><identifier>ISSN: 0376-8716</identifier><identifier>EISSN: 1879-0046</identifier><identifier>DOI: 10.1016/S0376-8716(00)00163-0</identifier><identifier>PMID: 11173173</identifier><identifier>CODEN: DADEDV</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Analysis of Variance ; Behavior, Addictive - psychology ; Biological and medical sciences ; Buprenorphine ; Buprenorphine - therapeutic use ; Buprenorphine tablet ; Chi-Square Distribution ; Controlled trial ; Double blind randomized trials ; Double-Blind Method ; Drug addictions ; Drug addicts ; Female ; Heroin Dependence - psychology ; Heroin Dependence - rehabilitation ; Heroin Dependence - urine ; Humans ; Male ; Medical sciences ; Methadone ; Methadone - therapeutic use ; Methadone maintenance ; Narcotic Antagonists - therapeutic use ; Opiates ; Opioid-Related Disorders - psychology ; Opioid-Related Disorders - rehabilitation ; Opioid-Related Disorders - urine ; Opioids ; Patient Compliance ; Toxicology ; Treatment</subject><ispartof>Drug and alcohol dependence, 2001-03, Vol.62 (1), p.97-104</ispartof><rights>2001 Elsevier Science Ireland Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-35f74d863bd8953b29e3939411ae1476005023d6ad4cc04341b3fe8406fe99063</citedby><cites>FETCH-LOGICAL-c445t-35f74d863bd8953b29e3939411ae1476005023d6ad4cc04341b3fe8406fe99063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0376871600001630$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27924,27925,31000,45780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=937986$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11173173$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Petitjean, Sylvie</creatorcontrib><creatorcontrib>Stohler, Rudolf</creatorcontrib><creatorcontrib>Déglon, Jean-Jacques</creatorcontrib><creatorcontrib>Livoti, Santino</creatorcontrib><creatorcontrib>Waldvogel, Doris</creatorcontrib><creatorcontrib>Uehlinger, Claude</creatorcontrib><creatorcontrib>Ladewig, Dieter</creatorcontrib><title>Double-blind randomized trial of buprenorphine and methadone in opiate dependence</title><title>Drug and alcohol dependence</title><addtitle>Drug Alcohol Depend</addtitle><description>This study compared the safety and efficacy of sublingual buprenorphine tablets with oral methadone in a population of opioid-dependent individuals in a double-blind, randomized, 6-week trial using a flexible dosing procedure. Fifty-eight patients seeking treatment for opioid dependence were recruited in three outpatient facilities and randomly assigned to substitution with buprenorphine or methadone. The retention rate was significantly better in the methadone maintained group (90 vs. 56%;
P<0.001). Subjects completing the study in both the treatment groups had similar proportions of opioid positive urine samples (buprenorphine 62%; methadone 59%) and positive urine specimens, as well as mean heroin craving scores decreased significantly over time (
P=0.035 and
P<0.001). The proportion of cocaine-positive toxicology results did not differ between groups. At week six mean stabilization doses were 10.5 mg per day for the sublingual buprenorphine tablet, and 69.8 mg per day for methadone, respectively. Patient performance during maintenance was similar in both the groups. The high attrition rate in the buprenorphine group during the induction phase might reflect inadequate induction doses. Thus, buprenorphine is a viable alternative for methadone in short-term maintenance treatment for heroin dependence if treatment induction is done with adequate dosages.</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Behavior, Addictive - psychology</subject><subject>Biological and medical sciences</subject><subject>Buprenorphine</subject><subject>Buprenorphine - therapeutic use</subject><subject>Buprenorphine tablet</subject><subject>Chi-Square Distribution</subject><subject>Controlled trial</subject><subject>Double blind randomized trials</subject><subject>Double-Blind Method</subject><subject>Drug addictions</subject><subject>Drug addicts</subject><subject>Female</subject><subject>Heroin Dependence - psychology</subject><subject>Heroin Dependence - rehabilitation</subject><subject>Heroin Dependence - urine</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methadone</subject><subject>Methadone - therapeutic use</subject><subject>Methadone maintenance</subject><subject>Narcotic Antagonists - therapeutic use</subject><subject>Opiates</subject><subject>Opioid-Related Disorders - psychology</subject><subject>Opioid-Related Disorders - rehabilitation</subject><subject>Opioid-Related Disorders - urine</subject><subject>Opioids</subject><subject>Patient Compliance</subject><subject>Toxicology</subject><subject>Treatment</subject><issn>0376-8716</issn><issn>1879-0046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>7QJ</sourceid><recordid>eNqFkF9L3jAUh4Ns6KvzIzgKg6EX1ZM3adJcjeG_CYLI9DqkySlmtE1N2sH26U19X_TScCDk8JzzCw8hRxROKVBx9huYFGUtqTgGOIHcYiXskBWtpSoBuPhEVm_IHtlP6Q_kIxTskj1KqWS5VuT-IsxNh2XT-cEV0Qwu9P4_umKK3nRFaItmHiMOIY5PfsAiA0WP05NxIb_8UITRmwkLhyMODgeLX8jn1nQJD7f3AXm8unw4_1Xe3l3fnP-8LS3n1VSyqpXc1YI1rlYVa9YKmWKKU2qQcikAKlgzJ4zj1gJnnDasxZqDaFEpEOyAfN_sHWN4njFNuvfJYteZAcOcdCVlRdd8AasNaGNIKWKrx-h7E_9pCnpxqV9d6kWUBtCvLjXkua_bgLnp0b1PbeVl4NsWMMmars32rE9vnGJS1Uv8jw2FWcZfj1En6xdRzke0k3bBf_CRF_XKjx0</recordid><startdate>20010301</startdate><enddate>20010301</enddate><creator>Petitjean, Sylvie</creator><creator>Stohler, Rudolf</creator><creator>Déglon, Jean-Jacques</creator><creator>Livoti, Santino</creator><creator>Waldvogel, Doris</creator><creator>Uehlinger, Claude</creator><creator>Ladewig, Dieter</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope></search><sort><creationdate>20010301</creationdate><title>Double-blind randomized trial of buprenorphine and methadone in opiate dependence</title><author>Petitjean, Sylvie ; Stohler, Rudolf ; Déglon, Jean-Jacques ; Livoti, Santino ; Waldvogel, Doris ; Uehlinger, Claude ; Ladewig, Dieter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-35f74d863bd8953b29e3939411ae1476005023d6ad4cc04341b3fe8406fe99063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Behavior, Addictive - psychology</topic><topic>Biological and medical sciences</topic><topic>Buprenorphine</topic><topic>Buprenorphine - therapeutic use</topic><topic>Buprenorphine tablet</topic><topic>Chi-Square Distribution</topic><topic>Controlled trial</topic><topic>Double blind randomized trials</topic><topic>Double-Blind Method</topic><topic>Drug addictions</topic><topic>Drug addicts</topic><topic>Female</topic><topic>Heroin Dependence - psychology</topic><topic>Heroin Dependence - rehabilitation</topic><topic>Heroin Dependence - urine</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methadone</topic><topic>Methadone - therapeutic use</topic><topic>Methadone maintenance</topic><topic>Narcotic Antagonists - therapeutic use</topic><topic>Opiates</topic><topic>Opioid-Related Disorders - psychology</topic><topic>Opioid-Related Disorders - rehabilitation</topic><topic>Opioid-Related Disorders - urine</topic><topic>Opioids</topic><topic>Patient Compliance</topic><topic>Toxicology</topic><topic>Treatment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Petitjean, Sylvie</creatorcontrib><creatorcontrib>Stohler, Rudolf</creatorcontrib><creatorcontrib>Déglon, Jean-Jacques</creatorcontrib><creatorcontrib>Livoti, Santino</creatorcontrib><creatorcontrib>Waldvogel, Doris</creatorcontrib><creatorcontrib>Uehlinger, Claude</creatorcontrib><creatorcontrib>Ladewig, Dieter</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><jtitle>Drug and alcohol dependence</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Petitjean, Sylvie</au><au>Stohler, Rudolf</au><au>Déglon, Jean-Jacques</au><au>Livoti, Santino</au><au>Waldvogel, Doris</au><au>Uehlinger, Claude</au><au>Ladewig, Dieter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Double-blind randomized trial of buprenorphine and methadone in opiate dependence</atitle><jtitle>Drug and alcohol dependence</jtitle><addtitle>Drug Alcohol Depend</addtitle><date>2001-03-01</date><risdate>2001</risdate><volume>62</volume><issue>1</issue><spage>97</spage><epage>104</epage><pages>97-104</pages><issn>0376-8716</issn><eissn>1879-0046</eissn><coden>DADEDV</coden><abstract>This study compared the safety and efficacy of sublingual buprenorphine tablets with oral methadone in a population of opioid-dependent individuals in a double-blind, randomized, 6-week trial using a flexible dosing procedure. Fifty-eight patients seeking treatment for opioid dependence were recruited in three outpatient facilities and randomly assigned to substitution with buprenorphine or methadone. The retention rate was significantly better in the methadone maintained group (90 vs. 56%;
P<0.001). Subjects completing the study in both the treatment groups had similar proportions of opioid positive urine samples (buprenorphine 62%; methadone 59%) and positive urine specimens, as well as mean heroin craving scores decreased significantly over time (
P=0.035 and
P<0.001). The proportion of cocaine-positive toxicology results did not differ between groups. At week six mean stabilization doses were 10.5 mg per day for the sublingual buprenorphine tablet, and 69.8 mg per day for methadone, respectively. Patient performance during maintenance was similar in both the groups. The high attrition rate in the buprenorphine group during the induction phase might reflect inadequate induction doses. Thus, buprenorphine is a viable alternative for methadone in short-term maintenance treatment for heroin dependence if treatment induction is done with adequate dosages.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>11173173</pmid><doi>10.1016/S0376-8716(00)00163-0</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0376-8716 |
| ispartof | Drug and alcohol dependence, 2001-03, Vol.62 (1), p.97-104 |
| issn | 0376-8716 1879-0046 |
| language | eng |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); ScienceDirect Freedom Collection 2022-2024; ScienceDirect Journals |
| subjects | Adult Analysis of Variance Behavior, Addictive - psychology Biological and medical sciences Buprenorphine Buprenorphine - therapeutic use Buprenorphine tablet Chi-Square Distribution Controlled trial Double blind randomized trials Double-Blind Method Drug addictions Drug addicts Female Heroin Dependence - psychology Heroin Dependence - rehabilitation Heroin Dependence - urine Humans Male Medical sciences Methadone Methadone - therapeutic use Methadone maintenance Narcotic Antagonists - therapeutic use Opiates Opioid-Related Disorders - psychology Opioid-Related Disorders - rehabilitation Opioid-Related Disorders - urine Opioids Patient Compliance Toxicology Treatment |
| title | Double-blind randomized trial of buprenorphine and methadone in opiate dependence |
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