HLA-B60 and B61 are strongly associated with ankylosing spondylitis in HLA-B27-negative Taiwan Chinese patients

Objectives. Carriage of HLA-B60 has been shown to increase the risk of ankylosing spondylitis (AS) in B27-positive Caucasian patients, but the association in B27-negative cases is less certain. This study assessed HLA class I gene associations in Chinese HLA-B27-negative AS patients. Methods. Forty-...

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Bibliographic Details
Published in:Rheumatology (Oxford, England) England), 2004-07, Vol.43 (7), p.839-842
Main Authors: Wei, J. C. C., Tsai, W. C., Lin, H. S., Tsai, C. Y., Chou, C. T.
Format: Article
Language:English
Subjects:
Adult
Ankylosing spondylitis
Biological and medical sciences
Case-Control Studies
China - ethnology
Diseases of the osteoarticular system
Female
Flow Cytometry
Genes, MHC Class I
HLA-B Antigens - analysis
HLA-B27 Antigen - analysis
HLA-B27-negative
HLA-class I genes
Humans
Immunophenotyping
Inflammatory joint diseases
Joints - diagnostic imaging
Male
Medical sciences
Middle Aged
Spondylitis, Ankylosing - diagnostic imaging
Spondylitis, Ankylosing - genetics
Spondylitis, Ankylosing - immunology
Taiwan
Ultrasonography, Doppler
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Summary:Objectives. Carriage of HLA-B60 has been shown to increase the risk of ankylosing spondylitis (AS) in B27-positive Caucasian patients, but the association in B27-negative cases is less certain. This study assessed HLA class I gene associations in Chinese HLA-B27-negative AS patients. Methods. Forty-one Chinese HLA-B27-negative AS patients fulfilling the modified New York diagnostic criteria for AS were recruited, and 11 383 HLA-B27-negative blood donors were used for comparison. HLA-A and -B typing was done with the microlymphocytotoxicity assay. Results. Among the B27-negative AS patients, 21 were male and 20 were female. Of HLA-B alleles, only B60 and B61 significantly increased susceptibility to AS in HLA-B27-negative patients (P
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/keh193