Prevalence of Pertussis Antibodies in Maternal Delivery, Cord, and Infant Serum

Background. Passively acquired maternal antibodies protect infants from many pathogens. With increasing reports of infant pertussis, we evaluated pertussis antibodies in maternal-infant paired sera from 1999–2000. Methods. Antibodies to pertussis toxin (PT), filamentous hemagglutinin (FHA), and fimb...

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Bibliographic Details
Published in:The Journal of infectious diseases 2004-07, Vol.190 (2), p.335-340
Main Authors: Healy, C. Mary, Munoz, Flor M., Rench, Marcia A., Halasa, Natasha, Edwards, Kathryn M., Baker, Carol J.
Format: Article
Language:English
Subjects:
Adhesins, Bacterial - immunology
Adult
Antibodies
Antibodies, Bacterial - blood
Antigens
Bacteria
Bacterial diseases
Biological and medical sciences
Bordetella pertussis - immunology
Ent and stomatologic bacterial diseases
Enzyme-Linked Immunosorbent Assay
Female
Fetal Blood - immunology
Fimbriae Proteins - immunology
Fundamental and applied biological sciences. Psychology
Hemagglutinins - immunology
Human bacterial diseases
Humans
Immunity, Maternally-Acquired
Immunization
Immunoglobulin G - blood
Infant
Infant, Newborn
Infants
Infections
Infectious diseases
Kinetics
Male
Medical sciences
Microbiology
Mothers
Pediatrics
Pertussis Toxin - immunology
Pregnancy
Vaccination
Virulence Factors, Bordetella - immunology
Whooping cough
Whooping Cough - immunology
Women
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Summary:Background. Passively acquired maternal antibodies protect infants from many pathogens. With increasing reports of infant pertussis, we evaluated pertussis antibodies in maternal-infant paired sera from 1999–2000. Methods. Antibodies to pertussis toxin (PT), filamentous hemagglutinin (FHA), and fimbrial proteins (FIM) were measured by validated IgG-specific enzyme-linked immunosorbant assay (ELISA) in 64 maternal-umbilical cord serum pairs and in 61 of 64 infant sera. Geometric mean concentrations (GMCs) of pertussis antibodies and cord:maternal GMC ratios were calculated. Results. Mean maternal age and gestation were 29.7 years (range, 19–42) and 39.3 weeks (range, 35.67–40.9), and 81% of mothers were white. GMCs of maternal antibodies at delivery (ELISA units/mL) were 2.4 for PT, 6.9 for FHA, and 13 for FIM. Cord GMCs were 169%, 178%, and 157% of maternal delivery values for PT, FHA, and FIM, respectively, demonstrating active placental transfer (P
ISSN:0022-1899
1537-6613
DOI:10.1086/421033