Numerical Study on the Multi-Region Bio-Heat Equation to Model Magnetic Fluid Hyperthermia (MFH) Using Low Curie Temperature Nanoparticles

This study develops and solves two-dimensional convective-conductive coupled partial differential equations based on Pennes' bio-heat transfer model using low Curie temperature nanoparticles (LCTNPs) to illustrate thermal behavior quantitatively within tumor-normal composite tissue by establish...

Full description

Saved in:
Bibliographic Details
Published in:IEEE transactions on nanobioscience 2008-12, Vol.7 (4), p.267-275
Main Authors: Zhang, Chuanqian, Johnson, Duane T., Brazel, Christopher S.
Format: Magazinearticle
Language:English
Subjects:
Animals
Bio-heat equation
Body Temperature
Boundary conditions
Computer Simulation
Energy Transfer
finite difference algorithm
Finite difference methods
heat transfer
Hot Temperature
Humans
Hyperthermia
Hyperthermia, Induced - methods
low Curie temperature nanoparticle
magnetic fluid hyperthermia
Magnetic liquids
Magnetics - methods
Microfluidics - methods
Models, Biological
Nanomedicine - methods
Nanoparticles
Nanoparticles - therapeutic use
Neoplasms
Neoplasms - physiopathology
Neoplasms - therapy
NÉel relaxation
Partial differential equations
Saturation magnetization
Steady-state
Temperature distribution
Therapy, Computer-Assisted - methods
Thermodynamics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study develops and solves two-dimensional convective-conductive coupled partial differential equations based on Pennes' bio-heat transfer model using low Curie temperature nanoparticles (LCTNPs) to illustrate thermal behavior quantitatively within tumor-normal composite tissue by establishing a multi-region finite difference algorithm. The model combines Neel relaxation and temperature-variant saturation magnetization derived from Brillouin Equation and Curie-Weiss Law. The numerical results indicate that different deposition patterns of LCTNP and boundary conditions directly effect the steady state temperature distribution. Compared with high Curie temperature nanoparticles (HCTNPs), optimized distributions of LCTNPs within tumorous tissue can be used to control the temperature increase in tumors for hyperthermia treatment using an external magnetic field while healthy tissue surrounding a tumor can be kept closer to normal body tissue, reducing the side effects observed in whole body and regional hyperthermia therapy.
ISSN:1536-1241
1558-2639
DOI:10.1109/TNB.2008.2011857