Voxel-based morphometry in adolescents with bipolar disorder: first results

Bipolar disorder is an increasingly recognized cause of significant morbidity in the pediatric age group. However, there is still a large degree of uncertainty regarding the underlying neurobiological deficits. In this preliminary study, we performed automated volumetric studies and whole-brain voxe...

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Bibliographic Details
Published in:Psychiatry research 2004-05, Vol.131 (1), p.57-69
Main Authors: Wilke, Marko, Kowatch, Robert A, DelBello, Melissa P, Mills, Neil P, Holland, Scott K
Format: Article
Language:English
Subjects:
Adolescent
Adult and adolescent clinical studies
Anterior cingulate
Basal ganglia
Basal Ganglia - pathology
Biological and medical sciences
Bipolar Disorder - diagnosis
Bipolar disorders
Brain - pathology
Brain Mapping
Cerebral Cortex - pathology
Child
Dominance, Cerebral - physiology
Female
Gyrus Cinguli - pathology
Humans
Image Interpretation, Computer-Assisted
Image Processing, Computer-Assisted
Imaging, Three-Dimensional
Magnetic Resonance Imaging
Male
Mathematical Computing
Medical sciences
Mood disorders
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Reference Values
Voxel-based morphometry
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Summary:Bipolar disorder is an increasingly recognized cause of significant morbidity in the pediatric age group. However, there is still a large degree of uncertainty regarding the underlying neurobiological deficits. In this preliminary study, we performed automated volumetric studies and whole-brain voxel-based morphometry (VBM) on gray matter. Imaging data from 10 adolescents with bipolar disorder were compared with data from 52 age- and gender-matched healthy controls. Previously defined brain parcellations and optimized VBM protocols were used, based on custom-made pediatric reference data. An additional, exploratory whole-brain comparison was also implemented. The volumetric region-of-interest study revealed significantly greater gray matter volume in central gray matter structures bilaterally (including the basal ganglia and the thalamus) and the left temporal lobe in the bipolar group. VBM confirmed bilaterally larger basal ganglia. Localized gray matter deficits in bipolar subjects were found in the medial temporal lobe, orbito-frontal cortex, and the anterior cingulate, confirming and extending earlier studies.
ISSN:0925-4927
0165-1781
1872-7506
DOI:10.1016/j.pscychresns.2004.01.004