Chromosomal aberrations in Korean nonsmall cell lung carcinomas: degenerate oligonucleotide primed polymerase chain reaction comparative genomic hybridization studies

Chromosomal aberrations were investigated in 48 Korean nonsmall cell carcinomas of the lung (NSCLC), by degenerate oligonucleotide primed polymerase chain reaction comparative genomic hybridization. These included 16 adenocarcinomas, 27 squamous cell carcinomas (SCCs), and 5 large-cell carcinomas. T...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 2004-07, Vol.152 (2), p.153-157
Main Authors: Park, Soo-Yeun, Kim, Yeol-Hong, In, Kwang-Ho, Chun, Yong-Hyuck, Park, Sun-Hwa
Format: Article
Language:English
Subjects:
Adenocarcinoma - epidemiology
Adenocarcinoma - genetics
Adenocarcinoma - pathology
Carcinoma, Large Cell - epidemiology
Carcinoma, Large Cell - genetics
Carcinoma, Large Cell - pathology
Carcinoma, Non-Small-Cell Lung - epidemiology
Carcinoma, Non-Small-Cell Lung - genetics
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Squamous Cell - epidemiology
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - pathology
Chromosome Aberrations
DNA Primers
DNA, Neoplasm - genetics
Gene Amplification
Gene Dosage
Humans
Korea - epidemiology
Lung Neoplasms - epidemiology
Lung Neoplasms - genetics
Nucleic Acid Hybridization
Polymerase Chain Reaction
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Summary:Chromosomal aberrations were investigated in 48 Korean nonsmall cell carcinomas of the lung (NSCLC), by degenerate oligonucleotide primed polymerase chain reaction comparative genomic hybridization. These included 16 adenocarcinomas, 27 squamous cell carcinomas (SCCs), and 5 large-cell carcinomas. The common sites of copy number increases were 3q26∼qter (23 cases, 48%); 8q23∼qter (46%); 20q13.1 (42%); 1q42∼qter (38%); 3q25 (38%); 21q22 (38%); and 22q13 (38%). DNA amplification was identified in 19 carcinomas (40%), and the frequent sites of amplification were 8q24 (seven cases), 3q26 (seven cases), and 3q27 (seven cases). The frequently under-represented chromosomal regions were Yq (38%), 4q25∼q26 (23%), and 4q31 (23%). In particular, gains of 3q26∼qter (74%), 15q (56%), and 19q (59%) and loss of 13q22∼q31 (26%) were more frequently detected in SCCs of the lung. These nonrandom aberrations can serve as starting points for the identification of potential oncogenes/tumor suppressor genes related to the tumorigenesis of Korean NSCLC.
ISSN:0165-4608
1873-4456
DOI:10.1016/j.cancergencyto.2003.10.016