Cardiac arrhythmia and nocturnal hypoglycaemia in type 1 diabetes--the 'dead in bed' syndrome revisited

Aims/hypothesis Sudden nocturnal death in type 1 diabetes ('dead in bed' syndrome) is thought to be due to ECG QT prolongation with subsequent ventricular tachyarrhythmia in response to nocturnal hypoglycaemia. We investigated this theoretical mechanism using continuous ECG and continuous...

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Bibliographic Details
Published in:Diabetologia 2009-01, Vol.52 (1), p.42-45
Main Authors: Gill, G. V, Woodward, A, Casson, I. F, Weston, P. J
Format: Article
Language:English
Subjects:
Adult
arrhythmia
Arrhythmias, Cardiac - epidemiology
Arrhythmias, Cardiac - physiopathology
Biological and medical sciences
Blood Glucose - analysis
Bradycardia - epidemiology
Cardiac arrhythmia
Cardiac dysrhythmias
Cardiology. Vascular system
Circadian Rhythm - physiology
Dead in bed syndrome
Diabetes
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - physiopathology
Diabetes. Impaired glucose tolerance
Electrocardiography
Endocrine pancreas. Apud cells (diseases)
Endocrinology
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Glucose monitoring
Heart
Heart Rate
Human Physiology
Humans
Hypoglycemia
Hypoglycemia - physiopathology
Insulin
insulin-dependent diabetes mellitus
Internal Medicine
Long QT Syndrome - epidemiology
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Monitoring systems
Monitoring, Ambulatory
Monitoring, Physiologic - methods
Nocturnal hypoglycaemia
Patients
Potassium
Short Communication
Sleep - physiology
Tachycardia, Ectopic Atrial - epidemiology
Young Adult
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Summary:Aims/hypothesis Sudden nocturnal death in type 1 diabetes ('dead in bed' syndrome) is thought to be due to ECG QT prolongation with subsequent ventricular tachyarrhythmia in response to nocturnal hypoglycaemia. We investigated this theoretical mechanism using continuous ECG and continuous glucose monitoring in a group of patients with type 1 diabetes. Methods Twenty-five patients with type 1 diabetes (age 20-50 years) underwent two separate 24 h ECG and continuous glucose monitoring periods. Patients were fully ambulant and carried out normal daily activities. Results There were 13 episodes (26% of recordings) of nocturnal hypoglycaemia, eight of
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-008-1177-7