C-reactive protein, the metabolic syndrome, and prediction of cardiovascular events in the Framingham Offspring Study

Inflammation (assessed by C-reactive protein [CRP]) and the metabolic syndrome (MetS) are associated with cardiovascular disease (CVD), but population-based data are limited. We assessed the cross-sectional relations of CRP to the MetS (National Cholesterol Education Program Expert Panel on Detectio...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2004-07, Vol.110 (4), p.380-385
Main Authors: Rutter, Martin K, Meigs, James B, Sullivan, Lisa M, D'Agostino, Sr, Ralph B, Wilson, Peter W F
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
C-Reactive Protein - analysis
Cardiovascular Diseases - blood
Cardiovascular Diseases - epidemiology
Cohort Studies
Cross-Sectional Studies
Female
Follow-Up Studies
Humans
Inflammation - blood
Insulin Resistance
Male
Metabolic Syndrome - blood
Metabolic Syndrome - epidemiology
Middle Aged
Predictive Value of Tests
Risk
Sex Factors
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Summary:Inflammation (assessed by C-reactive protein [CRP]) and the metabolic syndrome (MetS) are associated with cardiovascular disease (CVD), but population-based data are limited. We assessed the cross-sectional relations of CRP to the MetS (National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults, Adult Treatment Panel III definition) in 3037 subjects (1681 women; mean age, 54 years) and the utility of CRP and the MetS to predict new CVD events (n=189) over 7 years. MetS (> or =3 of 5 traits) was present in 24% of subjects; mean age-adjusted CRP levels for those with 0, 1, 2, 3, 4, or 5 MetS traits were 2.2, 3.5, 4.2, 6.0, or 6.6 mg/L, respectively (P trend
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.0000136581.59584.0e