Enantioselective synthesis of the dioxabicyclo[3.2.1]octane core of the zaragozic acids via intramolecular Wacker-type cyclisation reactions

Wacker-type cyclisation reactions provide an effective entry into the dioxabicyclo[3.2.1]octane core of the zaragozic acid analogues.

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2004-08, Vol.2 (15), p.2220-2228
Main Authors: Perlmutter, Patrick, Selajerern, Walailak, Vounatsos, Filisaty
Format: Article
Language:English
Subjects:
Antifungal Agents - chemical synthesis
Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis
Cyclization
Farnesyl-Diphosphate Farnesyltransferase - antagonists & inhibitors
Molecular Structure
Octanes - chemical synthesis
Stereoisomerism
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Description
Summary:Wacker-type cyclisation reactions provide an effective entry into the dioxabicyclo[3.2.1]octane core of the zaragozic acid analogues.
ISSN:1477-0520
1477-0539
DOI:10.1039/b406280a