Rat tail skin temperature regulation by estrogen, phytoestrogens and tamoxifen

Objective: Develop a rat model for the evaluation of estrogenic agents on estrogen deficiency-induced changes in thermoregulation. Methods: OVX rats are impaired in thermoregulation which manifests itself as an elevation in basal tail skin temperature (TST) and are less able to respond to temperatur...

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Bibliographic Details
Published in:Maturitas 2004-08, Vol.48 (4), p.463-471
Main Authors: Opas, Evan E, Jane Rutledge, Su, Vogel, Robert L, Rodan, Gideon A, Schmidt, Azriel
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Estrogen Antagonists - pharmacology
Estrogens - pharmacology
Female
Genital system. Reproduction
Gynecology. Andrology. Obstetrics
Medical sciences
Models, Animal
Ovariectomy
Pharmacology. Drug treatments
Phytoestrogen
Phytoestrogens - pharmacology
Puberal and climacteric disorders (male and female)
Rats
Rats, Sprague-Dawley
Skin Temperature - drug effects
Tail - drug effects
Tail - physiology
Tail skin temperature
Tamoxifen
Tamoxifen - pharmacology
Time Factors
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Summary:Objective: Develop a rat model for the evaluation of estrogenic agents on estrogen deficiency-induced changes in thermoregulation. Methods: OVX rats are impaired in thermoregulation which manifests itself as an elevation in basal tail skin temperature (TST) and are less able to respond to temperature changes than intact rats. Results: Administration of estrogen subcutaneously to estrogen-depleted rats either as depot formulation, biodegradable pellets, or daily injections, suppressed the increased TST. OVX rats maintained on a diet devoid of phytoestrogens had a higher TST by several degrees than OVX rats fed normal chow, offering greater ability to test estrogenic agents on thermoregulation. Depletion of estrogen in intact rats via chronic administration of leuprolide acetate, a GnRH agonist, also increased TST, which was in turn suppressed by estrogen. In intact rats, tamoxifen exhibited estrogen antagonistic activity elevating TST, while in OVX rats, tamoxifen acted as an agonist by suppressing TST. Conclusion: OVX rats kept on a diet devoid of phytoestrogens are a sensitive model for estrogen-dependent thermoregulation.
ISSN:0378-5122
1873-4111
DOI:10.1016/j.maturitas.2003.11.001