Activated protein C levels in Behçet's disease and risk of venous thrombosis

Summary Behçet's disease is a multi‐systemic inflammatory disorder of unknown cause. Most abnormalities have been associated with endothelial injury caused by vasculitis. Thrombosis occurs in about 25% of patients, although the mechanism is unknown. The objective of this study was to evaluate t...

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Bibliographic Details
Published in:British journal of haematology 2004-08, Vol.126 (4), p.550-556
Main Authors: Navarro, Silvia, Ricart, José María, Medina, Pilar, Vayá, Amparo, Villa, Piedad, Todolí, José, Estellés, Amparo, Micó, María Luisa, Aznar, Justo, España, Francisco
Format: Article
Language:English
Subjects:
activated protein C
Adolescent
Adult
Behcet Syndrome - blood
Behcet Syndrome - complications
Behcet Syndrome - drug therapy
Behcet Syndrome - physiopathology
Behçet's disease
Biological and medical sciences
Blood Coagulation
Blood Coagulation Factors - analysis
Female
Hematologic and hematopoietic diseases
Hematology
Humans
inflammation
Male
Medical sciences
Middle Aged
Protein C - analysis
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Thromboembolism - blood
Thromboembolism - etiology
thrombomodulin
Thrombophilia - blood
Thrombophilia - etiology
venous thrombosis
Venous Thrombosis - blood
Venous Thrombosis - etiology
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Summary:Summary Behçet's disease is a multi‐systemic inflammatory disorder of unknown cause. Most abnormalities have been associated with endothelial injury caused by vasculitis. Thrombosis occurs in about 25% of patients, although the mechanism is unknown. The objective of this study was to evaluate the protein C activation system in Behçet's disease and its correlation with venous thromboembolism (VTE). Thirty‐nine patients (12 with VTE) and 78 age‐ and sex‐matched controls were included in the study, and levels of protein C, protein S, activated protein C (APC), protein C inhibitor (PCI), soluble thrombomodulin (TM), antithrombin (AT), α1‐antitrypsin, fibrinogen, factor VIII, von Willebrand factor (VWF) and C‐reactive protein (CRP) were measured. APC and TM levels were significantly lower in patients than in controls, whereas protein S, AT, α1‐antitrypsin, fibrinogen, factor VIII, VWF and CRP levels were significantly higher in patients than in controls. APC, PCI and TM levels were lower in patients with VTE (0·65 ± 0·19 ng/ml, 86% ± 22% and 15·5 ± 7·1 ng/ml respectively) than in those without VTE (0·78 ± 0·17 ng/ml, 100% ± 15% and 22·1 ± 15·3 ng/ml) (P 
ISSN:0007-1048
1365-2141
DOI:10.1111/j.1365-2141.2004.05072.x