In situ inhibition of uterine activity by indomethacin: Possible relevance to preterm labor prevention after fetal surgery

This report is an analysis of the effects of local indomethacin delivery on uterine activity in vitro. Isolated strips of time-dated pregnant rats’ myometrium were placed within controlled tissue baths. Spontaneous muscular activity was recorded by a force transducer connected to a polygraph at cumu...

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Bibliographic Details
Published in:Journal of pediatric surgery 2004-08, Vol.39 (8), p.1173-1175
Main Authors: Garza, Jennifer, Clayton, Nicholas, Kaviani, Amir, Maher, Timothy J., Fauza, Dario
Format: Article
Language:English
Subjects:
Animals
Depression, Chemical
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Female
Fetal Diseases - surgery
fetal surgery
indomethacin
Indomethacin - pharmacology
Indomethacin - therapeutic use
myometrium
Myometrium - drug effects
Obstetric Labor, Premature - drug therapy
Obstetric Labor, Premature - prevention & control
Pregnancy
Premature labor
Rats
Rats, Wistar
Tocolytic Agents - pharmacology
Tocolytic Agents - therapeutic use
Uterine Contraction - drug effects
uterus
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Summary:This report is an analysis of the effects of local indomethacin delivery on uterine activity in vitro. Isolated strips of time-dated pregnant rats’ myometrium were placed within controlled tissue baths. Spontaneous muscular activity was recorded by a force transducer connected to a polygraph at cumulative concentrations of indomethacin. Statistical analysis was by single-factor analysis of variance (ANOVA), with P values of less than .05 considered significant. Within a narrow concentration range, the effects of indomethacin on frequency and amplitude of myometrial contractions were nonmonotonic, with an increase in frequency at levels that began to depress amplitude. However, both amplitude and frequency were significantly depressed and eventually totally abolished at most concentrations studied ( P < .05). Indomethacin administered in situ consistently inhibits or completely arrests overall myometrial activity. The concept of local myometrial delivery of indomethacin, possibly via slow release systems, may prove clinically useful as an adjuvant to its systemic administration in preterm labor prevention after fetal surgery, warranting further trials in vivo.
ISSN:0022-3468
1531-5037
DOI:10.1016/j.jpedsurg.2004.04.006