Exclusion of inflammation in the differential diagnosis of an elevated prostate-specific antigen (PSA)

Abstract Prostate inflammation can lead to an elevation in the serum PSA concentration and confound the use of PSA kinetics. This can have considerable clinical consequences, since these measurements form the basis for important clinical decisions. Thus, there has been investigation into ways to dec...

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Bibliographic Details
Published in:Urologic oncology 2009, Vol.27 (1), p.64-66
Main Authors: Loeb, Stacy, M.D, Gashti, Sara N., B.S, Catalona, William J., M.D
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - therapeutic use
Antibiotics
Biological and medical sciences
Biomarkers, Tumor - blood
Biopsy
Diagnosis, Differential
Early Detection of Cancer
Humans
Inflammation - blood
Inflammation - diagnosis
Male
Medical Oncology - methods
Medical sciences
Nephrology. Urinary tract diseases
Prevalence
Prostate biopsy
Prostate cancer
Prostate-Specific Antigen - biosynthesis
Prostatic Neoplasms - blood
Prostatic Neoplasms - diagnosis
Prostatitis
Prostatitis - blood
Prostatitis - diagnosis
PSA
Tumors
Tumors of the urinary system
Urinary tract. Prostate gland
Urology
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Summary:Abstract Prostate inflammation can lead to an elevation in the serum PSA concentration and confound the use of PSA kinetics. This can have considerable clinical consequences, since these measurements form the basis for important clinical decisions. Thus, there has been investigation into ways to decrease the confounding from inflammation, including repeat PSA measurements after a period of observation or a course of empiric antibiotics. This article reviews the evidence about elevations in PSA due to prostatitis and describes the controversy over the optimal approach to reduce its confounding impact on prostate cancer screening.
ISSN:1078-1439
1873-2496
DOI:10.1016/j.urolonc.2008.04.002