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The PfCRT (K76T) point mutation favours clone multiplicity and disease severity in Plasmodium falciparum infection

Summary In Orissa, a malaria‐hyperendemic area of India, we assessed the relationship between the PfCRT (K76T) point mutation of Plasmodium falciparum and the clinical severity of malaria. Forty uncomplicated and 36 severe malaria cases were selected, and parasite species, density and schizontaemia...

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Published in:Tropical medicine & international health 2004-08, Vol.9 (8), p.857-861
Main Authors: Ranjit, M. R., Das, A., Chhotray, G. P., Das, B. P., Das, B. N., Acharya, A. S.
Format: Article
Language:English
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Summary:Summary In Orissa, a malaria‐hyperendemic area of India, we assessed the relationship between the PfCRT (K76T) point mutation of Plasmodium falciparum and the clinical severity of malaria. Forty uncomplicated and 36 severe malaria cases were selected, and parasite species, density and schizontaemia determined by examination of Giemsa‐stained thick or thin blood films. The PfCRT point mutation was analysed by PCR–RFLP and genotypes of the parasite isolates investigated by nested PCR using the polymorphic region of the merozoite surface protein‐2. We found that (i) the prevalence of the PfCRT point mutation was significantly higher (P 
ISSN:1360-2276
1365-3156
DOI:10.1111/j.1365-3156.2004.01286.x