Oxyntomodulin and glicentin are potent inhibitors of the fed motility pattern in small intestine

• Published in: Neurogastroenterology and motility 2004-08, Vol.16 (4), p.455-463
• Main Authors: Pellissier, S., Sasaki, K., Le‐Nguyen, D., Bataille, D., Jarrousse, C.
• Format: Article
• Language: English
• Subjects: Animals; Eating - drug effects; Eating - physiology; Gastrointestinal Motility - drug effects; Gastrointestinal Motility - physiology; Glicentin; Glucagon - pharmacology; Glucagon-Like Peptides - pharmacology; Intestine, Small - drug effects; Intestine, Small - physiology; Male; myoelectrical activity; Oxyntomodulin; oxynto‐modulin; Peptide Fragments - pharmacology; Protein Precursors - pharmacology; Rats; Rats, Wistar; transit
• ISSN: 1350-1925; 1365-2982
• DOI: 10.1111/j.1365-2982.2004.00528.x

Glicentin (GLIC) and oxyntomodulin (OXM or GLIC 33‐69) are gut hormones which regulate digestion. They are known to reduce digestive secretions and to delay gastric emptying. Their biological activities on intestinal motility are still unknown. The effect of a systemic GLIC or OXM increase was investigated in rats on the food intake, the postprandial myoelectrical activity of small intestine and the orocaecal transit. An OXM or GLIC i.v. infusion was applied during the 5 min preceding food onset and during the first 15 min of food intake. This determined a three‐ to fourfold increase of the preprandial OXM–GLIC level. The OXM or GLIC plasma increase did not modify food intake. OXM infusion slowed down gastric emptying when the stomach contained 3/4 of the ingested food (before T 3 h). The quantity of food delivered in jejunum was subsequently smaller (P