Layer-Specific Expression of Multiple Cadherins in the Developing Visual Cortex (V1) of the Ferret

Cadherins are superfamily of Ca2+-dependent transmembrane glycoproteins with more than 100 members. They play a role in a wide variety of developmental mechanisms, including cell proliferation, cell differentiation, cell–cell recognition, neurite outgrowth and synaptogenesis. We cloned 16 novel memb...

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Published in:Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2009-02, Vol.19 (2), p.388-401
Main Authors: Krishna-K, Nuernberger, Monique, Weth, Franco, Redies, Christoph
Format: Article
Language:English
Subjects:
Animals
Brain Mapping
Cadherins - biosynthesis
Cadherins - genetics
cell adhesion
Cloning, Molecular
cortical plate
corticogenesis
DNA Primers
DNA, Complementary - biosynthesis
DNA, Complementary - genetics
Female
Ferrets
Fluorescein-5-isothiocyanate - analogs & derivatives
germinal zones
In Situ Hybridization
In Situ Hybridization, Fluorescence
Mustela putorius furo
Pregnancy
Reverse Transcriptase Polymerase Chain Reaction
RNA - biosynthesis
RNA - genetics
Tyramine - analogs & derivatives
Visual Cortex - growth & development
δ-protocadherins
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Summary:Cadherins are superfamily of Ca2+-dependent transmembrane glycoproteins with more than 100 members. They play a role in a wide variety of developmental mechanisms, including cell proliferation, cell differentiation, cell–cell recognition, neurite outgrowth and synaptogenesis. We cloned 16 novel members of the classic cadherin and δ-protocadherin subgroups from ferret brain. Their expression patterns were investigated by in situ hybridization in the developing primary visual cortex (V1) of the ferret. Fifteen out of the 16 cadherins are expressed in a spatiotemporally restricted fashion throughout development. Each layer of V1 can be characterized by the combinatorial expression of a subset of cadherins at any given developmental stage. A few cadherins are expressed by subsets of neurons in specific layers or by neurons dispersed throughout all cortical layers. Generally, the expression of protocadherins is more widespread, whereas that of classic cadherins is more restricted to specific layers. At the V1/V2 boundary, changes in layer-specific cadherin expression are observed. In conclusion, our results suggest that cadherins provide a code of potentially adhesive cues for layer formation in ferret V1. The persistence of expression in the adult suggests a functional role also in the mature cortex.
ISSN:1047-3211
1460-2199
DOI:10.1093/cercor/bhn090