analysis of genetics and associated autoimmune diseases in Chinese vitiligo patients

Vitiligo is a common skin and hair depigmentary disorder that results from selective destruction of melanocytes. It occurs in a typical multifactorial, polygenic inheritance. Several studies have indicated that vitiligo is associated with some autoimmune diseases. In this paper we examined 6,516 vit...

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Bibliographic Details
Published in:Archives of Dermatological Research 2009-02, Vol.301 (2), p.167-173
Main Authors: Zhang, Zheng, Xu, Sheng-Xin, Zhang, Feng-Yu, Yin, Xian-Yong, Yang, Sen, Xiao, Feng-Li, Du, Wen-Hui, Wang, Jian-Feng, Lv, Yong-Mei, Tang, Hua-Yang, Zhang, Xue-Jun
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Allergic diseases
Alopecia Areata - ethnology
Alopecia Areata - genetics
Arthritis, Rheumatoid - ethnology
Arthritis, Rheumatoid - genetics
Asthma - epidemiology
Autoimmune Diseases - ethnology
Autoimmune Diseases - genetics
Biological and medical sciences
Child
Child, Preschool
China - epidemiology
Dermatology
Diabetes Mellitus - epidemiology
Diseases of the osteoarticular system
Female
Health Surveys
Humans
Immunopathology
Infant
Inflammatory joint diseases
Male
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Original Paper
Pigmentary diseases of the skin
Prevalence
Psoriasis - ethnology
Psoriasis - genetics
Skin allergic diseases. Stinging insect allergies
Urticaria - ethnology
Urticaria - genetics
Vitiligo - ethnology
Vitiligo - genetics
Young Adult
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Summary:Vitiligo is a common skin and hair depigmentary disorder that results from selective destruction of melanocytes. It occurs in a typical multifactorial, polygenic inheritance. Several studies have indicated that vitiligo is associated with some autoimmune diseases. In this paper we examined 6,516 vitiligo patients including clinical characteristics, familial involvement, and their association with other autoimmune diseases. Compared with sporadic vitiligo probands, familial vitiligo probands have earlier age onset and longer disease duration. The prevalences of four autoimmune diseases namely rheumatoid arthritis, chronic urticaria, alopecia areata and psoriasis, were significantly elevated in generalized vitiligo probands and their first-degree relatives. The prevalences of chronic urticaria, rheumatoid arthritis, psoriasis were much higher in familial generalized vitiligo probands. In addition, the prevalences of diabetes mellitus and asthma were also higher in familial vitiligo probands. These findings indicate that generalized vitiligo may share common genetic aetiologic links with other autoimmune diseases, and the genetic component of familial generalized vitiligo is stronger.
ISSN:0340-3696
1432-069X
DOI:10.1007/s00403-008-0900-z