Brain versus lung : Hierarchy of feedback loops in single-ventricle patients with superior cavopulmonary connection

CO2 vasodilates and O2 vasoconstricts the cerebral vascular bed; the opposite is true in the lungs. When the brain and lungs are connected exclusively in series, which feedback loop predominates is unknown. The circulation of the superior cavopulmonary connection (SCPC) provides a unique physiology...

Full description

Saved in:
Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2004-09, Vol.110 (11), p.147-152
Main Authors: FOGEL, Mark A, BURNING, Suzanne, WERNOVSKY, Gil, POLLOCK, Avrum N, GAYNOR, J. William, NICOLSON, Susan
Format: Article
Language:English
Subjects:
Aorta - physiopathology
Biological and medical sciences
Blood and lymphatic vessels
Carbon Dioxide - administration & dosage
Carbon Dioxide - blood
Cardiology. Vascular system
Cerebrovascular Circulation
Child, Preschool
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Feedback, Physiological - physiology
Female
Fontan Procedure
General and cellular metabolism. Vitamins
Heart Ventricles - abnormalities
Heart Ventricles - surgery
Hemorheology
Humans
Infant
Jugular Veins - physiopathology
Magnetic Resonance Imaging
Male
Medical sciences
Neurology
Organ Specificity
Oxygen - administration & dosage
Oxygen - blood
Pharmacology. Drug treatments
Prospective Studies
Pulmonary Artery - surgery
Pulmonary Circulation
Vascular diseases and vascular malformations of the nervous system
Vasoconstriction
Vasodilation
Vena Cava, Inferior - surgery
Vena Cava, Superior - surgery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:CO2 vasodilates and O2 vasoconstricts the cerebral vascular bed; the opposite is true in the lungs. When the brain and lungs are connected exclusively in series, which feedback loop predominates is unknown. The circulation of the superior cavopulmonary connection (SCPC) provides a unique physiology to answer this question. To determine cerebral and pulmonary blood flow and to establish the hierarchy of cerebral and pulmonary feedback mechanisms, 12 intubated, ventilated, single-ventricle patients in SCPC physiology (age 2.2+/-0.5 years) underwent magnetic resonance imaging velocity mapping of their jugular veins and aorta in room air, hypercarbia, and 100% O2. Flows in these vessels and arterial blood gases were measured. With 22+/-6 torr CO2 (Pco2) increased from 40 to 63 mm Hg, P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.0000138346.34596.99