Submicroscopic Plasmodium falciparum infections and multiplicity of infection in matched peripheral, placental and umbilical cord blood samples from Gabonese women

Summary In malaria‐endemic regions, pregnant women are more susceptible to malarial infections than non‐pregnant women. The main objective of this study, which was conducted in the malaria hyperendemic town of Lambaréné (Gabon, Central Africa), was to characterize Plasmodium falciparum infections in...

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Bibliographic Details
Published in:Tropical medicine & international health 2004-09, Vol.9 (9), p.949-958
Main Authors: Mayengue, Pembe Issamou, Rieth, Horst, Khattab, Ayman, Issifou, Saadou, Kremsner, Peter G., Klinkert, Mo‐Quen, Ntoumi, Francine
Format: Article
Language:English
Subjects:
Adolescent
Adult
Analysis of Variance
Animals
Antigens, Protozoan - analysis
Antigens, Protozoan - genetics
Biological and medical sciences
Biomarkers
Blood
DNA, Protozoan - analysis
Eukaryotes
Female
Fetal Blood - parasitology
Gabon - epidemiology
General aspects
Genetics
Genotype
Gravidity
Humans
Malaria
Malaria, Falciparum - diagnosis
Malaria, Falciparum - epidemiology
Malaria, Falciparum - parasitology
Medical sciences
Molecular Sequence Data
MSP 2 marker
multiplicity of infections
Placenta - parasitology
Plasmodium falciparum
Plasmodium falciparum - genetics
Plasmodium falciparum - isolation & purification
polymerase chain reaction
Polymerase Chain Reaction - methods
Pregnancy
Pregnancy Complications, Parasitic - diagnosis
Pregnancy Complications, Parasitic - epidemiology
Pregnancy Complications, Parasitic - parasitology
Prevalence
Protozoan Proteins - analysis
Protozoan Proteins - genetics
submicroscopic infections
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Summary:Summary In malaria‐endemic regions, pregnant women are more susceptible to malarial infections than non‐pregnant women. The main objective of this study, which was conducted in the malaria hyperendemic town of Lambaréné (Gabon, Central Africa), was to characterize Plasmodium falciparum infections in peripheral, placental and cord blood from women of different gravidities with submicroscopic infections. Using the P. falciparum merozoite surface protein 2 (MSP 2)* gene as a polymorphic marker in polymerase chain reactions, we analysed genetic diversity and multiplicity of infection in isolates from all three kinds of samples of 184 pregnant women at delivery. We detected infection in 44% of the women who were originally negative by microscopy. Equally important was the finding that the placenta had the highest prevalence of infection (P 
ISSN:1360-2276
1365-3156
DOI:10.1111/j.1365-3156.2004.01294.x