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Comparison of the Two Types of Bioresorbable Barriers to Prevent Intra-Abdominal Adhesions in Rats
Purpose The aim of this study was to evaluate the efficacy of two absorbable film barriers, polylactic acid and sodium hyaluronate–carboxymethyl cellulose, in preventing postoperative intra-abdominal adhesions, inflammation, and fibrosis in an animal model. Methods Forty Wistar albino rats were grou...
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| Published in: | Journal of gastrointestinal surgery 2009-02, Vol.13 (2), p.282-286 |
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| Main Authors: | , , , , |
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| Language: | English |
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| container_end_page | 286 |
| container_issue | 2 |
| container_start_page | 282 |
| container_title | Journal of gastrointestinal surgery |
| container_volume | 13 |
| creator | Ersoy, Eren Ozturk, Vedat Yazgan, Aylin Ozdogan, Mehmet Gundogdu, Haldun |
| description | Purpose
The aim of this study was to evaluate the efficacy of two absorbable film barriers, polylactic acid and sodium hyaluronate–carboxymethyl cellulose, in preventing postoperative intra-abdominal adhesions, inflammation, and fibrosis in an animal model.
Methods
Forty Wistar albino rats were grouped as polylactic acid, sodium hyaluronate–carboxymethyl cellulose, and control. All rats underwent laparotomy with subsequent cecal wall abrasion and abdominal wall injury. The two treatment groups received polylactic acid or sodium hyaluronate–carboxymethyl cellulose film barriers, while control group received nothing. On postoperative day 21, three observers graded the intra-abdominal adhesions and resected specimens. Fibrosis, inflammation, and adhesions were graded using quantitative scoring systems.
Results
When compared to control group, polylactic acid group showed significantly less inflammation and adhesion (
p
|
| doi_str_mv | 10.1007/s11605-008-0678-5 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66871655</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>66871655</sourcerecordid><originalsourceid>FETCH-LOGICAL-c436t-22167cd0dc9f6b45e6a4ad4782f642541283f725c3816b0a9893577a460bcefb3</originalsourceid><addsrcrecordid>eNp1kN9rFDEQx4Motlb_AF8kIPgWzWTz6x6vR7WFgiIn-BaS3Vm7ZXdzZvaU_vfmuAOL4FOGzGe-M3wYew3yPUjpPhCAlUZI6YW0zgvzhJ2Dd43QVtmntZYrEMqY72fsBdG9lOAk-OfsrELOgVLnLG3ytItloDzz3PPlDvn2d-bbhx3S4eNyyAUplxTTiPwyljJgIb5k_qXgL5wXfjMvJYp16vI0zHHk6-4Oacgz8WHmX-NCL9mzPo6Er07vBfv28Wq7uRa3nz_dbNa3otWNXYRSYF3bya5d9TZpgzbq2GnnVW-1MhqUb3qnTNt4sEnGlV81xrmorUwt9qm5YO-OubuSf-6RljAN1OI4xhnznoK13oE1poJv_wHv877U2ykAVCuNdkZWCo5UWzJRwT7syjDF8hBAhoP-cNQfqv5w0B8OyW9Oyfs0Yfd34uS7AuoIUG3NP7A8Wv3f1D8l6I7T</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1112234750</pqid></control><display><type>article</type><title>Comparison of the Two Types of Bioresorbable Barriers to Prevent Intra-Abdominal Adhesions in Rats</title><source>Springer Nature</source><creator>Ersoy, Eren ; Ozturk, Vedat ; Yazgan, Aylin ; Ozdogan, Mehmet ; Gundogdu, Haldun</creator><creatorcontrib>Ersoy, Eren ; Ozturk, Vedat ; Yazgan, Aylin ; Ozdogan, Mehmet ; Gundogdu, Haldun</creatorcontrib><description>Purpose
The aim of this study was to evaluate the efficacy of two absorbable film barriers, polylactic acid and sodium hyaluronate–carboxymethyl cellulose, in preventing postoperative intra-abdominal adhesions, inflammation, and fibrosis in an animal model.
Methods
Forty Wistar albino rats were grouped as polylactic acid, sodium hyaluronate–carboxymethyl cellulose, and control. All rats underwent laparotomy with subsequent cecal wall abrasion and abdominal wall injury. The two treatment groups received polylactic acid or sodium hyaluronate–carboxymethyl cellulose film barriers, while control group received nothing. On postoperative day 21, three observers graded the intra-abdominal adhesions and resected specimens. Fibrosis, inflammation, and adhesions were graded using quantitative scoring systems.
Results
When compared to control group, polylactic acid group showed significantly less inflammation and adhesion (
p
< 0.005), while there was no significant difference for fibrosis. Sodium hyaluronate–carboxymethyl cellulose group has showed significantly less adhesions (
p
< 0.005), but there were no significant differences among fibrosis and inflammation when compared to control group. There were no significant differences between polylactic acid and sodium hyaluronate–carboxymethyl cellulose groups on adhesion formation, inflammation, or fibrosis.
Conclusions
Placement of polylactic acid or sodium hyaluronate–carboxymethyl cellulose film barriers between injured surfaces is associated with a significantly reduced rate of postoperative adhesions. No superiority was detected between two barriers.</description><identifier>ISSN: 1091-255X</identifier><identifier>EISSN: 1873-4626</identifier><identifier>DOI: 10.1007/s11605-008-0678-5</identifier><identifier>PMID: 18777122</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Abdomen ; Abdominal Wall - pathology ; Abdominal Wall - surgery ; Animals ; Biocompatible Materials - therapeutic use ; Biodegradable materials ; Female ; Gastroenterology ; Hyaluronic Acid - therapeutic use ; Lactic Acid - therapeutic use ; Laparotomy - adverse effects ; Medicine ; Medicine & Public Health ; Membranes, Artificial ; Original Article ; Plastics ; Polyesters ; Polylactic acid ; Polymers ; Polymers - therapeutic use ; Rats ; Rats, Wistar ; Surgery ; Tissue Adhesions - etiology ; Tissue Adhesions - prevention & control</subject><ispartof>Journal of gastrointestinal surgery, 2009-02, Vol.13 (2), p.282-286</ispartof><rights>The Society for Surgery of the Alimentary Tract 2008</rights><rights>The Society for Surgery of the Alimentary Tract 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-22167cd0dc9f6b45e6a4ad4782f642541283f725c3816b0a9893577a460bcefb3</citedby><cites>FETCH-LOGICAL-c436t-22167cd0dc9f6b45e6a4ad4782f642541283f725c3816b0a9893577a460bcefb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18777122$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ersoy, Eren</creatorcontrib><creatorcontrib>Ozturk, Vedat</creatorcontrib><creatorcontrib>Yazgan, Aylin</creatorcontrib><creatorcontrib>Ozdogan, Mehmet</creatorcontrib><creatorcontrib>Gundogdu, Haldun</creatorcontrib><title>Comparison of the Two Types of Bioresorbable Barriers to Prevent Intra-Abdominal Adhesions in Rats</title><title>Journal of gastrointestinal surgery</title><addtitle>J Gastrointest Surg</addtitle><addtitle>J Gastrointest Surg</addtitle><description>Purpose
The aim of this study was to evaluate the efficacy of two absorbable film barriers, polylactic acid and sodium hyaluronate–carboxymethyl cellulose, in preventing postoperative intra-abdominal adhesions, inflammation, and fibrosis in an animal model.
Methods
Forty Wistar albino rats were grouped as polylactic acid, sodium hyaluronate–carboxymethyl cellulose, and control. All rats underwent laparotomy with subsequent cecal wall abrasion and abdominal wall injury. The two treatment groups received polylactic acid or sodium hyaluronate–carboxymethyl cellulose film barriers, while control group received nothing. On postoperative day 21, three observers graded the intra-abdominal adhesions and resected specimens. Fibrosis, inflammation, and adhesions were graded using quantitative scoring systems.
Results
When compared to control group, polylactic acid group showed significantly less inflammation and adhesion (
p
< 0.005), while there was no significant difference for fibrosis. Sodium hyaluronate–carboxymethyl cellulose group has showed significantly less adhesions (
p
< 0.005), but there were no significant differences among fibrosis and inflammation when compared to control group. There were no significant differences between polylactic acid and sodium hyaluronate–carboxymethyl cellulose groups on adhesion formation, inflammation, or fibrosis.
Conclusions
Placement of polylactic acid or sodium hyaluronate–carboxymethyl cellulose film barriers between injured surfaces is associated with a significantly reduced rate of postoperative adhesions. No superiority was detected between two barriers.</description><subject>Abdomen</subject><subject>Abdominal Wall - pathology</subject><subject>Abdominal Wall - surgery</subject><subject>Animals</subject><subject>Biocompatible Materials - therapeutic use</subject><subject>Biodegradable materials</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Hyaluronic Acid - therapeutic use</subject><subject>Lactic Acid - therapeutic use</subject><subject>Laparotomy - adverse effects</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Membranes, Artificial</subject><subject>Original Article</subject><subject>Plastics</subject><subject>Polyesters</subject><subject>Polylactic acid</subject><subject>Polymers</subject><subject>Polymers - therapeutic use</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Surgery</subject><subject>Tissue Adhesions - etiology</subject><subject>Tissue Adhesions - prevention & control</subject><issn>1091-255X</issn><issn>1873-4626</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp1kN9rFDEQx4Motlb_AF8kIPgWzWTz6x6vR7WFgiIn-BaS3Vm7ZXdzZvaU_vfmuAOL4FOGzGe-M3wYew3yPUjpPhCAlUZI6YW0zgvzhJ2Dd43QVtmntZYrEMqY72fsBdG9lOAk-OfsrELOgVLnLG3ytItloDzz3PPlDvn2d-bbhx3S4eNyyAUplxTTiPwyljJgIb5k_qXgL5wXfjMvJYp16vI0zHHk6-4Oacgz8WHmX-NCL9mzPo6Er07vBfv28Wq7uRa3nz_dbNa3otWNXYRSYF3bya5d9TZpgzbq2GnnVW-1MhqUb3qnTNt4sEnGlV81xrmorUwt9qm5YO-OubuSf-6RljAN1OI4xhnznoK13oE1poJv_wHv877U2ykAVCuNdkZWCo5UWzJRwT7syjDF8hBAhoP-cNQfqv5w0B8OyW9Oyfs0Yfd34uS7AuoIUG3NP7A8Wv3f1D8l6I7T</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>Ersoy, Eren</creator><creator>Ozturk, Vedat</creator><creator>Yazgan, Aylin</creator><creator>Ozdogan, Mehmet</creator><creator>Gundogdu, Haldun</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20090201</creationdate><title>Comparison of the Two Types of Bioresorbable Barriers to Prevent Intra-Abdominal Adhesions in Rats</title><author>Ersoy, Eren ; Ozturk, Vedat ; Yazgan, Aylin ; Ozdogan, Mehmet ; Gundogdu, Haldun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-22167cd0dc9f6b45e6a4ad4782f642541283f725c3816b0a9893577a460bcefb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Abdomen</topic><topic>Abdominal Wall - pathology</topic><topic>Abdominal Wall - surgery</topic><topic>Animals</topic><topic>Biocompatible Materials - therapeutic use</topic><topic>Biodegradable materials</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Hyaluronic Acid - therapeutic use</topic><topic>Lactic Acid - therapeutic use</topic><topic>Laparotomy - adverse effects</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Membranes, Artificial</topic><topic>Original Article</topic><topic>Plastics</topic><topic>Polyesters</topic><topic>Polylactic acid</topic><topic>Polymers</topic><topic>Polymers - therapeutic use</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Surgery</topic><topic>Tissue Adhesions - etiology</topic><topic>Tissue Adhesions - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ersoy, Eren</creatorcontrib><creatorcontrib>Ozturk, Vedat</creatorcontrib><creatorcontrib>Yazgan, Aylin</creatorcontrib><creatorcontrib>Ozdogan, Mehmet</creatorcontrib><creatorcontrib>Gundogdu, Haldun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastrointestinal surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ersoy, Eren</au><au>Ozturk, Vedat</au><au>Yazgan, Aylin</au><au>Ozdogan, Mehmet</au><au>Gundogdu, Haldun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of the Two Types of Bioresorbable Barriers to Prevent Intra-Abdominal Adhesions in Rats</atitle><jtitle>Journal of gastrointestinal surgery</jtitle><stitle>J Gastrointest Surg</stitle><addtitle>J Gastrointest Surg</addtitle><date>2009-02-01</date><risdate>2009</risdate><volume>13</volume><issue>2</issue><spage>282</spage><epage>286</epage><pages>282-286</pages><issn>1091-255X</issn><eissn>1873-4626</eissn><abstract>Purpose
The aim of this study was to evaluate the efficacy of two absorbable film barriers, polylactic acid and sodium hyaluronate–carboxymethyl cellulose, in preventing postoperative intra-abdominal adhesions, inflammation, and fibrosis in an animal model.
Methods
Forty Wistar albino rats were grouped as polylactic acid, sodium hyaluronate–carboxymethyl cellulose, and control. All rats underwent laparotomy with subsequent cecal wall abrasion and abdominal wall injury. The two treatment groups received polylactic acid or sodium hyaluronate–carboxymethyl cellulose film barriers, while control group received nothing. On postoperative day 21, three observers graded the intra-abdominal adhesions and resected specimens. Fibrosis, inflammation, and adhesions were graded using quantitative scoring systems.
Results
When compared to control group, polylactic acid group showed significantly less inflammation and adhesion (
p
< 0.005), while there was no significant difference for fibrosis. Sodium hyaluronate–carboxymethyl cellulose group has showed significantly less adhesions (
p
< 0.005), but there were no significant differences among fibrosis and inflammation when compared to control group. There were no significant differences between polylactic acid and sodium hyaluronate–carboxymethyl cellulose groups on adhesion formation, inflammation, or fibrosis.
Conclusions
Placement of polylactic acid or sodium hyaluronate–carboxymethyl cellulose film barriers between injured surfaces is associated with a significantly reduced rate of postoperative adhesions. No superiority was detected between two barriers.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>18777122</pmid><doi>10.1007/s11605-008-0678-5</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1091-255X |
| ispartof | Journal of gastrointestinal surgery, 2009-02, Vol.13 (2), p.282-286 |
| issn | 1091-255X 1873-4626 |
| language | eng |
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| source | Springer Nature |
| subjects | Abdomen Abdominal Wall - pathology Abdominal Wall - surgery Animals Biocompatible Materials - therapeutic use Biodegradable materials Female Gastroenterology Hyaluronic Acid - therapeutic use Lactic Acid - therapeutic use Laparotomy - adverse effects Medicine Medicine & Public Health Membranes, Artificial Original Article Plastics Polyesters Polylactic acid Polymers Polymers - therapeutic use Rats Rats, Wistar Surgery Tissue Adhesions - etiology Tissue Adhesions - prevention & control |
| title | Comparison of the Two Types of Bioresorbable Barriers to Prevent Intra-Abdominal Adhesions in Rats |
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