Long-term effects of vaccination on attentional performance

To investigate the possible influence of stimulation of the immune system on cognitive tasks, healthy volunteers were vaccinated against hepatitis B and tested over a 6 month-period in a simple reaction times and the Stroop task. In general, the “Stroop effect” demonstrates that both the name and me...

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Bibliographic Details
Published in:Vaccine 2004-09, Vol.22 (29), p.3877-3881
Main Authors: Nicoletti, Roberto, Adolfo Porro, Carlo, Brighetti, Gianni, Monti, Daniela, Pagnoni, Giuseppe, Guido, Marcello, Rubichi, Sandro, Franceschi, Claudio
Format: Article
Language:English
Subjects:
Adult
Antigens
Applied microbiology
Attention
Biological and medical sciences
Cognition
Competition
Cytokines
Cytokines - analysis
Double-Blind Method
Fundamental and applied biological sciences. Psychology
Hepatitis
Hepatitis B Antibodies - blood
Hepatitis B Vaccines - administration & dosage
Hepatitis B virus
Humans
Hypotheses
Immune system
Immune–cognitive effects
Male
Medical research
Microbiology
Motor ability
Reaction Time
Stroop task
Studies
Time Factors
Vaccination
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Summary:To investigate the possible influence of stimulation of the immune system on cognitive tasks, healthy volunteers were vaccinated against hepatitis B and tested over a 6 month-period in a simple reaction times and the Stroop task. In general, the “Stroop effect” demonstrates that both the name and meaning of a word are automatically processed even when voluntary attention is trying hard not to process them. Unlike placebo group, vaccinated subjects showed a persistent lack of the classical Stroop effect. These findings may be explained by a constraint satisfaction model of the Stroop task, assuming a selective weakening of the connection matrix, and suggest that immune–cognitive effects may occur, besides the well known immune–cognitive influences like those elicited by emotional stress.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2004.04.008