Biodegradable poly(ethylene glycol) hydrogels crosslinked with genipin for tissue engineering applications

In this study amino‐terminated poly(ethylene glycol) (PEG‐diamine) hydrogels were crosslinked with genipin, a chemical naturally derived from the gardenia fruit. Dissolution, swelling, and PEG–genipin release properties were determined. The dissolution studies indicated that the hydrogels are water...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biomedical materials research 2004-10, Vol.71B (1), p.181-187
Main Authors: Moffat, Kristen L., Marra, Kacey G.
Format: Article
Language:English
Subjects:
Adhesives
Animals
Aorta
Biocompatible Materials
biodegradable hydrogel
Cell Adhesion
Gardenia
genipin
Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry
Iridoid Glycosides
Iridoids
Materials Testing - methods
Microscopy, Electron, Scanning
Muscle, Smooth, Vascular - cytology
Muscle, Smooth, Vascular - physiology
poly(ethylene glycol)
Polyethylene Glycols - chemistry
Pyrans
Rats
smooth muscle cells
Surface Properties
Tissue Engineering - methods
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this study amino‐terminated poly(ethylene glycol) (PEG‐diamine) hydrogels were crosslinked with genipin, a chemical naturally derived from the gardenia fruit. Dissolution, swelling, and PEG–genipin release properties were determined. The dissolution studies indicated that the hydrogels are water soluble, and that the dissolution rate was concentration, mass, and temperature dependent. The dissolution rates are easily tailored from 3 min to >100 days. The PEG–genipin release study indicated that the greatest release occurs within the first 24 h of immersion in water, and that incubation at 37 °C elicits a greater initial release than samples incubated at room temperature for all genipin concentrations. Through scanning electron microscopy it was observed that the hydrogels are porous, and surface morphology changes before and after swelling. Furthermore, smooth muscle cell (SMC) adhesion studies indicated that the PEG–genipin hydrogel is a suitable substrate for SMC seeding. Overall, the results of these studies indicate that PEG–genipin hydrogels may provide potential scaffolding for a variety of tissue engineering applications. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 71B: 181–187, 2004
ISSN:1552-4973
0021-9304
1552-4981
DOI:10.1002/jbm.b.30070