A case of autoimmune thyroiditis and membranoproliferative glomerulonephritis

Thyroid hormones play an important role in the growth of the kidney and maintenance of its functions. Prolonged hypothyroidism is known to be accompanied by changes in renal morphology such as thickening of the glomerular and tubular basement membranes as well as increased mesangial matrix. Increase...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2009, Vol.24 (1), p.193-197
Main Authors: Gurkan, Sevgi, Dikman, Steven, Saland, M. Jeffrey
Format: Article
Language:English
Subjects:
Brief Report
Capillaries - ultrastructure
Care and treatment
Development and progression
Female
Glomerulonephritis
Glomerulonephritis, Membranous - complications
Glomerulonephritis, Membranous - immunology
Graves Disease - complications
Graves Disease - immunology
Graves Disease - physiopathology
Health aspects
Humans
Lymphomatoid Papulosis - complications
Lymphomatoid Papulosis - immunology
Lymphomatoid Papulosis - physiopathology
Medicine & Public Health
Mesangial Cells - ultrastructure
Nephrology
Nephrosis, Lipoid - complications
Nephrosis, Lipoid - immunology
Nephrosis, Lipoid - physiopathology
Patient outcomes
Pediatrics
Podocytes - ultrastructure
Proteinuria - etiology
Proteinuria - immunology
Proteinuria - physiopathology
Thymoma - complications
Thymoma - immunology
Thymoma - physiopathology
Thyroiditis, Autoimmune
Thyroiditis, Autoimmune - complications
Thyroiditis, Autoimmune - immunology
Thyroiditis, Autoimmune - physiopathology
Urology
Young Adult
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Description
Summary:Thyroid hormones play an important role in the growth of the kidney and maintenance of its functions. Prolonged hypothyroidism is known to be accompanied by changes in renal morphology such as thickening of the glomerular and tubular basement membranes as well as increased mesangial matrix. Increased transcapillary leakage of plasma proteins leading to proteinuria and generalized edema is also a known complication of hypothyroidism. In particular, autoimmune thyroiditis is associated with proteinuria. Most previous reports of autoimmune thyroiditis with nephrotic syndrome have demonstrated mixed pathological morphology marked by predominant membranous glomerulopathy. Here we present a patient whose initial presentation with profound hypothyroidism and autoimmune thyroiditis was dominated by nephrotic syndrome secondary to type 1 membranoproliferative glomerulonephritis (MPGN). The association of MPGN and autoimmune thyroiditis is very rare.
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-007-0668-y