Do gene-environment interactions influence fasting plasma lipids? A study of twins

Background  The aims of this study were to determine the influence of smoking, alcohol consumption, physical activity and hormone replacement therapy (HRT) on lipids, independently of genetic factors, and to detect whether gene–environment interactions influence these associations. Materials and met...

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Bibliographic Details
Published in:European journal of clinical investigation 2004-09, Vol.34 (9), p.590-598
Main Authors: Greenfield, J. R., Samaras, K., Jenkins, A. B., Kelly, P. J., Spector, T. D., Campbell, L. V.
Format: Article
Language:English
Subjects:
Adult
Aged
Alcohol
Alcohol Drinking - blood
apolipoproteins
Biological and medical sciences
Body Composition
Exercise - physiology
Female
gene-environment interaction
General aspects
Hormone Replacement Therapy
Humans
lipids
Lipids - blood
Medical sciences
Middle Aged
smoking
Smoking - blood
Tobacco, tobacco smoking
Toxicology
twin study
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Summary:Background  The aims of this study were to determine the influence of smoking, alcohol consumption, physical activity and hormone replacement therapy (HRT) on lipids, independently of genetic factors, and to detect whether gene–environment interactions influence these associations. Materials and methods  Fasting plasma total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, apolipoproteins AI and B and lipoprotein(a) were measured in 685 female twins (96 monozygotic, 230 dizygotic pairs and 33 singletons). Results  Smokers had higher triglyceride and lower HDL cholesterol levels than never‐smokers (P 
ISSN:0014-2972
1365-2362
DOI:10.1111/j.1365-2362.2004.01389.x