Modeling mitochondrial function in aging neurons

Mitochondria and aging are fast becoming two of the most paired terms in biology. As a crucial nexus for the cell, mitochondria are involved in numerous essential aspects of cell function, from energy production via the respiratory chain to steroid biosynthesis, heme assembly, pyrimidine biosynthesi...

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Bibliographic Details
Published in:Trends in neurosciences (Regular ed.) 2004-10, Vol.27 (10), p.601-606
Main Author: Melov, Simon
Format: Article
Language:English
Subjects:
Aging
Aging - metabolism
Alzheimer Disease - metabolism
Animals
Biological and medical sciences
Development. Senescence. Regeneration. Transplantation
Disease Models, Animal
DNA Damage
DNA, Mitochondrial - metabolism
Free Radicals - metabolism
Fundamental and applied biological sciences. Psychology
Humans
Mice
Mitochondria - metabolism
Mitochondrial DNA
Models, Animal
Neurons
Neurons - metabolism
Oxidative Stress
Reactive Oxygen Species - metabolism
Vertebrates: nervous system and sense organs
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Summary:Mitochondria and aging are fast becoming two of the most paired terms in biology. As a crucial nexus for the cell, mitochondria are involved in numerous essential aspects of cell function, from energy production via the respiratory chain to steroid biosynthesis, heme assembly, pyrimidine biosynthesis, the tricarboxylic acid cycle, and apoptosis. Mitochondria are also the main producers of reactive oxygen species within the cell. Theories about aging have revolved around mitochondria for decades, but it is only in the past few years that animal models have started to give significant insights into mitochondria-mediated pathophysiology that might be intimately associated with aging. This review will highlight several new animal models of mitochondrial dysfunction in the context of aging.
ISSN:0166-2236
1878-108X
DOI:10.1016/j.tins.2004.08.004