MF59®-Adjuvanted H5N1 Vaccine Induces Immunologic Memory and Heterotypic Antibody Responses in Non-Elderly and Elderly Adults

Pathogenic avian influenza virus (H5N1) has the potential to cause a major global pandemic in humans. Safe and effective vaccines that induce immunologic memory and broad heterotypic response are needed. Healthy adults aged 18-60 and > 60 years (n = 313 and n = 173, respectively) were randomized...

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Bibliographic Details
Published in:PloS one 2009-02, Vol.4 (2), p.e4384
Main Authors: Banzhoff, Angelika, Gasparini, Roberto, Laghi-Pasini, Franco, Staniscia, Tommaso, Durando, Paolo, Montomoli, Emanuele, Capecchi, Pamela, di Giovanni, Pamela, Sticchi, Laura, Gentile, Chiara, Hilbert, Anke, Brauer, Volker, Tilman, Sandrine, Podda, Audino
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - administration & dosage
Adjuvants, Immunologic - pharmacology
Adolescent
Adult
Adults
Age Distribution
Aged
Antibodies
Antibodies, Heterophile - immunology
Antibody Formation - drug effects
Antibody Formation - immunology
Antigens
Avian flu
Clinical trials
Cross Reactions
Dosage
Drug dosages
Epidemiology
Female
Formulations
Geriatrics
Health care
Health sciences
Health surveillance
Hemagglutination - drug effects
Hemagglutination inhibition
Hemolysis - drug effects
Humans
Hygiene
Immune response
Immune response (humoral)
Immune system
Immunization, Secondary
Immunogenicity
Immunologic Memory - drug effects
Immunologic Memory - immunology
Immunological memory
Immunology
Immunology/Immunity to Infections
Infectious Diseases/Viral Infections
Influenza
Influenza A Virus, H5N1 Subtype - drug effects
Influenza A Virus, H5N1 Subtype - immunology
Influenza Vaccines - adverse effects
Influenza Vaccines - immunology
Injection
Laboratories
Male
Manganese
Neutralization Tests
Older people
Pain
Pandemics
Polysorbates - administration & dosage
Preventive medicine
Production capacity
Public health
Respiratory Medicine/Respiratory Infections
Squalene - administration & dosage
Squalene - immunology
Vaccination
Vaccines
Virology/Vaccines
Viruses
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Items that cite this one
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