A study of parenteral versus enteral nutrition following caecal ligation and puncture in the rat: Influence on survival and tissue protein turnover

Background & aims: Methods of nutritional management in abdominal sepsis remain controversial. Methods: Sprague Dawley rats were either fed via a central line in the right internal jugular vein or duodenally via a gastrostomy tube, and were randomised to undergo either caecal ligation and punctu...

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Bibliographic Details
Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2004-10, Vol.23 (5), p.1135-1145
Main Authors: Scarlett, Christopher J., O’leary, Michael J., Kee, Anthony J., Nielsen, Aiqun, Sevette, Andre, Baxter, Robert C., Smith, Ross C.
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Bacterial Infections - metabolism
Bacterial Infections - therapy
Biological and medical sciences
Carrier Proteins - metabolism
Cecal Diseases - metabolism
Cecal Diseases - therapy
Emergency and intensive care: renal failure. Dialysis management
Enteral nutrition
Enteral Nutrition - adverse effects
Glycoproteins - metabolism
Insulin-like growth factor
Insulin-Like Growth Factor Binding Protein 1 - metabolism
Insulin-Like Growth Factor I - metabolism
Intensive care medicine
Liver - metabolism
Male
Medical sciences
Muscle Proteins - metabolism
Parenteral Nutrition
Protein turnover
Random Allocation
Rats
Rats, Sprague-Dawley
Sepsis
Survival Analysis
Treatment Outcome
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Summary:Background & aims: Methods of nutritional management in abdominal sepsis remain controversial. Methods: Sprague Dawley rats were either fed via a central line in the right internal jugular vein or duodenally via a gastrostomy tube, and were randomised to undergo either caecal ligation and puncture (CLP) or laparotomy only. Post-operatively, animals received either parenteral nutrition, enteral nutrition or saline only (parenteral and enteral nutrition protocols were isocaloric and isonitrogenous). After 72 h, fractional rate of protein synthesis ( K s, %/day) was measured in gastrocnemius muscle and liver, and protein breakdown was measured in incubated epitrochlearis muscles. Serum insulin-like growth factor-I (IGF-I), acid-labile subunit (ALS) and IGF binding protein-1 (IGFBP-1) levels were determined by specific radioimmunoassay methods. Results: After CLP, when compared with starved animals, only enteral nutrition resulted in a significant decrease in survival to 72 h ( P
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2004.02.008