Pharmacokinetic evaluation of linezolid in patients with major thermal injuries

Aims To evaluate the pharmacokinetics of linezolid following its administration in patients with major thermal injuries and in a group of healthy volunteers. Methods In an open-label, multicentre design with two parallel groups, a group of patients with major thermal injuries (>20% body area) and...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2009-03, Vol.63 (3), p.553-559
Main Authors: Lovering, A. M., Le Floch, R., Hovsepian, L., Stephanazzi, J., Bret, P., Birraux, G., Vinsonneau, C.
Format: Article
Language:English
Subjects:
Acetamides - administration & dosage
Acetamides - pharmacokinetics
Adult
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - pharmacokinetics
Antibiotics
Antibiotics. Antiinfectious agents. Antiparasitic agents
Area Under Curve
Biological and medical sciences
Burn treatment
Burns
Chromatography, High Pressure Liquid
Drug dosages
Female
human
Humans
Infusions, Intravenous
Linezolid
Male
Medical sciences
Metabolic Clearance Rate
Middle Aged
oxazolidinone
Oxazolidinones - administration & dosage
Oxazolidinones - pharmacokinetics
Pharmacology
Pharmacology. Drug treatments
Plasma - chemistry
Time Factors
Traumas. Diseases due to physical agents
Urine - chemistry
Young Adult
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Summary:Aims To evaluate the pharmacokinetics of linezolid following its administration in patients with major thermal injuries and in a group of healthy volunteers. Methods In an open-label, multicentre design with two parallel groups, a group of patients with major thermal injuries (>20% body area) and a group of age-, sex- and weight-matched healthy volunteers, subjects received a single 600 mg intravenous dose of linezolid. Serial blood and urine collections were made and the concentrations of linezolid in these samples were determined by HPLC. Non-compartmental analyses were used to describe the pharmacokinetic disposition of linezolid. Results Cmax concentrations and the volume of distribution at steady state (Vss) were not statistically different (P > 0.05) between the two groups of subjects. In contrast, values describing clearance [elimination rate constant (kel), t1/2 and mean residence time (MRT)] were significantly different (P 
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dkn541