In the Golden Age of Organocatalysis

The term “organocatalysis” describes the acceleration of chemical reactions through the addition of a substoichiometric quantity of an organic compound. The interest in this field has increased spectacularly in the last few years as result of both the novelty of the concept and, more importantly, th...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2004-10, Vol.43 (39), p.5138-5175
Main Authors: Dalko, Peter I., Moisan, Lionel
Format: Article
Language:English
Subjects:
asymmetric catalysis
chiral auxiliaries
organocatalysis
synthetic methods
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Summary:The term “organocatalysis” describes the acceleration of chemical reactions through the addition of a substoichiometric quantity of an organic compound. The interest in this field has increased spectacularly in the last few years as result of both the novelty of the concept and, more importantly, the fact that the efficiency and selectivity of many organocatalytic reactions meet the standards of established organic reactions. Organocatalytic reactions are becoming powerful tools in the construction of complex molecular skeletons. The diverse examples show that in recent years organocatalysis has developed within organic chemistry into its own subdiscipline, whose “Golden Age” has already dawned. Metal‐free synthesis: An increasing number of asymmetric organic reactions can be catalyzed by a chiral organic molecule. Although substrate dependency remains an important issue in many cases, a large number of organocatalytic transformations are as efficient as current standards in asymmetric synthesis demand (see example).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200400650