Cytokines and Chemokines in Idiopathic Intracranial Hypertension

Background.— The pathogenesis of idiopathic intracranial hypertension (IIH) remains unclear and as such it remains a diagnosis of exclusion. Objectives.— To identify cerebrospinal fluid (CSF) and serum cytokine and chemokine profiles associated with IIH. Method.— Semiquantitative assessment with cyt...

Full description

Saved in:
Bibliographic Details
Published in:Headache 2009-02, Vol.49 (2), p.282-285
Main Authors: Dhungana, Samish, Sharrack, Basil, Woodroofe, Nicola
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
chemokine
Chemokines - analysis
Chemokines - metabolism
cytokine
Cytokines - analysis
Cytokines - metabolism
Enzyme-Linked Immunosorbent Assay
Female
Hematologic and hematopoietic diseases
Humans
idiopathic intracranial hypertension
leptin
Medical sciences
Middle Aged
Neurology
Platelet diseases and coagulopathies
Pseudotumor Cerebri - blood
Pseudotumor Cerebri - cerebrospinal fluid
Vascular diseases and vascular malformations of the nervous system
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background.— The pathogenesis of idiopathic intracranial hypertension (IIH) remains unclear and as such it remains a diagnosis of exclusion. Objectives.— To identify cerebrospinal fluid (CSF) and serum cytokine and chemokine profiles associated with IIH. Method.— Semiquantitative assessment with cytokine antibody arrays was used to detect the relative expression of 42 different cytokines and chemokines in the CSF and serum of 8 IIH patients and 8 controls. Subsequently, quantitative assay with enzyme linked immunosorbent assay was performed for chemokine CCL2, interleukin‐1 alpha (IL‐1α), and leptin. Results.— Cytokine antibody array showed elevated levels of CCL2 in the CSF and CCL7, CCL8, IL‐1α, and leptin levels in serum in IIH patients compared with controls. Subsequent quantitative assessment with enzyme linked immunosorbent assay showed significantly elevated CSF CCL2 in IIH patients compared with controls (P 
ISSN:0017-8748
1526-4610
DOI:10.1111/j.1526-4610.2008.001329.x