Synthesis and antimicrobial activities of some new triazolothiadiazoles bearing 4-methylthiobenzyl moiety

A series of substituted triazolothiadiazoles ( 6a– j and 7a– j) have been synthesized by condensing 4-amino-3-[4-methylthiobenzyl]-4 H-1,2,4-triazole-5-thiol ( 5) with substituted aryl furoic acids/aromatic acids in the presence of POCl 3. The triazole ( 5) was obtained by the fusion of 4-methylthio...

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Bibliographic Details
Published in:European journal of medicinal chemistry 2009-02, Vol.44 (2), p.551-557
Main Authors: Prasad, D. Jagadeesh, Ashok, Mithun, Karegoudar, Prakash, Poojary, Boja, Holla, B. Shivarama, Kumari, Nalilu Sucheta
Format: Article
Language:English
Subjects:
Anti-Infective Agents - chemical synthesis
Anti-Infective Agents - pharmacology
Antibacterial
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal
Antifungal agents
Biological and medical sciences
General aspects
Medical sciences
Methylthiobenzyl moiety
Microbial Sensitivity Tests
Molecular Structure
Pharmacology. Drug treatments
Spectrum Analysis
Structure-Activity Relationship
Thiadiazoles - chemical synthesis
Thiadiazoles - pharmacology
Triazoles
Triazolothiadiazole
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Summary:A series of substituted triazolothiadiazoles ( 6a– j and 7a– j) have been synthesized by condensing 4-amino-3-[4-methylthiobenzyl]-4 H-1,2,4-triazole-5-thiol ( 5) with substituted aryl furoic acids/aromatic acids in the presence of POCl 3. The triazole ( 5) was obtained by the fusion of 4-methylthiophenyl acetic acid ( 4) with thiocarbohydrazide. The structures of newly synthesized compounds are characterized by elemental analysis, IR, 1H NMR and mass spectroscopic studies and were screened for their antimicrobial activities. The preliminary results revealed that some of the compounds exhibited promising antimicrobial activities. [Display omitted]
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2008.03.025