The detection of sLFA-3 in plasma of patients with hemorrhagic fever with renal syndrome

Hemorrhagic fever with renal syndrome (HFRS) is an acute viral disease characterized by endothelial dysfunction. The cellular immune response, especially the virus-specific CD8+ T lymphocytes, is known to attack vascular endothelial cells (VEC) and to contribute to the diffuse damage and penetrabili...

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Bibliographic Details
Published in:Clinical and experimental medicine 2009-03, Vol.9 (1), p.67-71
Main Authors: Xie, Ming, Chen, Ping, He, Lin-jing, Qi, Bao-tai, Wang, Ping, Wang, Xiao-fang, Ren, Hui-xun
Format: Article
Language:English
Subjects:
Antigens
Blood Urea Nitrogen
CD58 Antigens - blood
Cellular biology
Creatinine - urine
Endothelial Cells - physiology
Gene expression
Hematology
Hemorrhagic Fever with Renal Syndrome - blood
Hemorrhagic Fever with Renal Syndrome - immunology
Humans
Immune system
Internal Medicine
Kidney diseases
Lymphocytes
Medicine
Medicine & Public Health
Oncology
Short Communication
Viruses
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Summary:Hemorrhagic fever with renal syndrome (HFRS) is an acute viral disease characterized by endothelial dysfunction. The cellular immune response, especially the virus-specific CD8+ T lymphocytes, is known to attack vascular endothelial cells (VEC) and to contribute to the diffuse damage and penetrability increasing of VEC. Lymphocyte function associated antigen 3 (LFA-3) is expressed on T lymphocytes and VEC, which is contributed to the activation of T lymphocytes. The expression of LFA-3 on the activated T lymphocytes and VEC is highly increased, which can exfoliate into plasma to increase the level of soluble LFA-3 (sLFA-3) in plasma. So the change of sLFA-3 levels is correlated with the activation of T lymphocytes. In this study we detected the levels of sLFA-3 in plasma of patients with HFRS. We examined the levels of sLFA-3 in plasma samples collected from 53 HFRS patients by double antibody sandwich ELISA. We found variable, but persistently elevated levels of sLFA-3 throughout the various phases and types of the HFRS disease, which suggest that sLFA-3 levels have correlation with disease stages. Moreover, elevated sLFA-3 levels are closely correlated to the severity of HFRS and the degree of kidney damage.
ISSN:1591-8890
1591-9528
DOI:10.1007/s10238-008-0007-z