Effect of xenon anaesthesia on accuracy of cardiac output measurement using partial CO2 rebreathing

Summary Cardiac output (CO) determination based on partial CO2 rebreathing has recently been introduced into clinical practice. The determination of flow is crucial for exact CO readings and the physical properties of xenon, i.e. high density and viscosity, may influence flow readings. This study co...

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Bibliographic Details
Published in:Anaesthesia 2004-11, Vol.59 (11), p.1104-1110
Main Authors: Bein, B., Hanne, P., Hanss, R., Renner, J., Weber, B., Steinfath, M., Scholz, J., Tonner, P. H.
Format: Article
Language:English
Subjects:
Aged
Anaesthetics
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anesthetics, Inhalation - pharmacology
Anesthetics, Intravenous - pharmacology
Anthropometry
Bias
Biological and medical sciences
Capnography - methods
Carbon dioxide
Carbon Dioxide - blood
cardiac output
Cardiac Output - drug effects
Cardiology
Echocardiography, Transesophageal - methods
Female
Humans
inhalational
intraoperative
Male
Medical sciences
Middle Aged
Monitoring
Monitoring, Intraoperative - methods
Partial Pressure
Studies
Xenon
Xenon - pharmacology
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Summary:Summary Cardiac output (CO) determination based on partial CO2 rebreathing has recently been introduced into clinical practice. The determination of flow is crucial for exact CO readings and the physical properties of xenon, i.e. high density and viscosity, may influence flow readings. This study compared echocardiography‐derived CO measurements with the partial rebreathing method during total intravenous (TIVA) vs. xenon‐based anaesthesia. Thirty‐nine patients ASA physical status III undergoing aortic reconstruction were randomly assigned to receive either xenon (Xe, n = 20) or TIVA (T, n = 19) based general anaesthetic. Paired measurements were taken before xenon administration, after xenon administration, before and after clamping of the abdominal aorta and after declamping and at corresponding time points in the TIVA group. Data were analysed with a Bland‐Altmann plot. Bias and precision were acceptable and comparable before xenon administration (T 0.54 ± 0.92 l.min−1 vs. Xe 0.11 ± 1.1 l.min−1), but after xenon administration CO was largely overestimated by partial CO2 rebreathing (T 0.04 ± 0.91 l.min−1 vs. Xe −4.0 ± 2.1 l.min−1). In the TIVA group, bias and precision after declamping increased significantly (P 
ISSN:0003-2409
1365-2044
DOI:10.1111/j.1365-2044.2004.03897.x